86031-05-2

Upstream product

• 91312-73-1 (4R,6R)-6-(2-Cyclohexyl-ethyl)-tetrahydro-pyran-2,4-diol 
• 86031-00-7 tert-Butyl-[(2R,4R,6R)-2-(2-cyclohexyl-ethyl)-6-methoxy-tetrahydro-pyran-4-yloxy]-diphenyl-silane 
• 91327-65-0 tert-Butyl-[(2S,4R,6S)-2-((E)-2-cyclohexyl-vinyl)-6-methoxy-tetrahydro-pyran-4-yloxy]-dimethyl-silane 
• 86030-96-8 (2S,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-carbaldehyde 
• 35166-78-0 cyclohexylmethyl magnesium bromide 
• 86030-93-5 tert-Butyl-((2S,4R,6S)-2-methoxy-6-trityloxymethyl-tetrahydro-pyran-4-yloxy)-diphenyl-silane 
• 86030-94-6 methyl 3-O-(tert-butyldiphenylsilyl)-2,4-dideoxy-β-D-erythro-hexopyranoside 
• 86030-97-9 1-[(2S,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-2-cyclohexyl-ethanol 
• 86030-92-4 methyl 2,4-dideoxy-6-O-(triphenylmethyl)-α-D-erythro-hexopyranoside 
• 120185-81-1 (R)-7-Cyclohexyl-5-((R)-3-hydroxy-1-methyl-propoxy)-3-oxo-heptanoic acid methyl ester 
• 120185-80-0 (2S,4R)-2-(2-Cyclohexyl-ethyl)-4-methyl-[1,3]dioxane 
• 91312-68-4 methyl 3-O-(tert-butyldimethylsilyl)-2,4-dideoxy-6-oxo-α-D-erythro-hexopyranoside 
• 91312-72-0 methyl 3-O-(tert-butyldimethylsilyl)-2,4,6-trideoxy-6-(cyclohexylmethyl)-α-D-erythro-hexopyranoside 
• 91312-63-9 methyl 3-O-(tert-butyldimethylsilyl)-2,4-dideoxy-6-hydroxy-α-D-erythro-hexopyranoside 

Relevant academic research and scientific papers

Application of sulfur ylide mediated epoxidations in the asymmetric synthesis of β-hydroxy-δ-lactones. Synthesis of a mevinic acid analogue and (+)-prelactone B

Catalytic and stoichiometric asymmetric sulfur ylide reactions were employed to prepare alkyl-aryl epoxide intermediates in a convergent manner. These epoxides were utilized in efficient syntheses of the mevinic acid analogue 1 and prelactone B. Graphical abstract.

Asymmetric Synthesis via Acetal Templates. 15. The Preparation of Enantiomerically Pure Mevinolin Analogs

An efficient asymmetric synthesis of the hydroxylactone moiety of mevinolin 1 is described.The key step is the TiCl4-catalyzed coupling reaction of acetals 3a and 3b derived from (R)-1,3-butanediol with 1,3-bis(trimethylsilyloxy)-1-methoxybuta-

MEVINIC ACIDS AND ANALOGUES: PREPARATION OF A KEY CHIRAL INTERMEDIATE

The preparation of methyl 3-O-tert-butyldiphenylsilyl-2,4-dideoxy-β-D-erytrohexopyranoside, a key chiral intermediate for mevinic acids, and its elaboration into four mevinate analogues are described.