86030-94-6

Basic information

• Product Name: methyl 3-O-(tert-butyldiphenylsilyl)-2,4-dideoxy-β-D-erythro-hexopyranoside
• Synonyms: methyl 3-O-(tert-butyldiphenylsilyl)-2,4-dideoxy-β-D-erythro-hexopyranoside
• CAS NO: 86030-94-6
• Molecular Weight: 400.59
• Mol File: 86030-94-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: methyl 3-O-(tert-butyldiphenylsilyl)-2,4-dideoxy-β-D-erythro-hexopyranoside(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-O-(tert-butyldiphenylsilyl)-2,4-dideoxy-β-D-erythro-hexopyranoside(86030-94-6)
• EPA Substance Registry System: methyl 3-O-(tert-butyldiphenylsilyl)-2,4-dideoxy-β-D-erythro-hexopyranoside(86030-94-6)

Safety Data

• Hazardous Substances Data: 86030-94-6(Hazardous Substances Data)

Upstream product

• 915201-16-0 (3R,5S)-3-tert-butyldiphenylsilyloxy-5,6-(isopropylidenedioxy)hexanal 
• 149-73-5 trimethyl orthoformate 
• 86030-92-4 methyl 2,4-dideoxy-6-O-(triphenylmethyl)-α-D-erythro-hexopyranoside 
• 94480-27-0 (5S)-5-<(phenylmethoxy)methyl>-3-<(1,3-dioxolan-2-yl)methyl>-4,5-dihydroisoxazole 
• 94480-28-1 (S)-5-Benzyloxy-1-[1,3]dioxolan-2-yl-4-hydroxy-pentan-2-one 
• 94480-26-9 (2S,6S)-tetrahydro-2-methoxy-6-<(phenylmethoxy)methyl>-4H-pyran-4-one 
• 94371-04-7 methyl 2,4-dideoxy-6-O-(phenylmethyl)-α-D-erythro-hexopyranoside 
• 94480-29-2 (2S)-2-benzyloxymethyl-2,3-dihydro-4H-pyran-4-one 
• 94371-09-2 methyl 3-O-(tert-butyldiphenylsilyl)-2,4-dideoxy-6-O-(phenylmethyl)-α-D-erythro-hexopyranoside 
• 94371-07-0 (5S)-5-<(1R)-1,2-dihydroxyethyl>-3-<(1,3-dioxolan-2-yl)methyl>-4,5-dihydroisoxazole 
• 94371-08-1 (5S)-5-(Hydroxymethyl)-3-<(1,3-dioxolan-2-yl)methyl)>-4,5-dihydroisoxazole 
• 90344-31-3 (5S)-5-<(4R)-(2,2-dimethyl-1,3-dioxolan-4-yl)>-3-<(1,3-dioxolan-2-yl)methyl>-4,5-dihydroisoxazole 
• 82891-99-4 ethylene ketal of 3-nitropropanal 
• 91312-53-7 ethyl (3R,5S)-5,6-O-isopropylidene-3,5,6-trihydroxyhexanoate 

Downstream Products

• 915201-17-1 (2S,4R,6S)-2-(p-chlorobenzenesulfonyloxy)methyl-4-tert-butyldiphenylsilyloxy-6-methoxytetrahydropyran 
• 92714-69-7 (1S,3S,4aR,7S,8S,8aS)-8-{2-[(2R,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-ethyl}-3,7-dimethyl-1,2,3,4,4a,7,8,8a-octahydro-naphthalen-1-ol 
• 92714-69-7 (1R,3R,4aS,7R,8R,8aR)-8-{2-[(2R,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-ethyl}-3,7-dimethyl-1,2,3,4,4a,7,8,8a-octahydro-naphthalen-1-ol 
• 92714-68-6 C₄₅H₆₀O₅S₃Si 
• 92714-68-6 C₄₅H₆₀O₅S₃Si 
• 77517-29-4 (+)-Dihydromevinolin 
• 86031-05-2 (4R,6R)-6-(2-cyclohexylethyl)-4-hydroxytetrahydropyran-2-one 
• 86030-98-0 1-[(2S,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-2-phenyl-ethanol 
• 86030-97-9 1-[(2S,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-2-cyclohexyl-ethanol 
• 86031-04-1 tert-Butyl-((2R,4R,6S)-2-methoxy-6-phenoxymethyl-tetrahydro-pyran-4-yloxy)-diphenyl-silane 
• 86031-01-8 tert-Butyl-((2R,4R,6R)-2-methoxy-6-phenethyl-tetrahydro-pyran-4-yloxy)-diphenyl-silane 
• 86031-00-7 tert-Butyl-[(2R,4R,6R)-2-(2-cyclohexyl-ethyl)-6-methoxy-tetrahydro-pyran-4-yloxy]-diphenyl-silane 
• 86031-02-9 tert-Butyl-((2R,4R,6R)-2-methoxy-6-pentyl-tetrahydro-pyran-4-yloxy)-diphenyl-silane 
• 86117-01-3 (4R,6R)-(+)-4-hydroxy-6-(2-phenylethyl)-tetrahydro-2H-pyran-2-one 

Relevant articles and documents

Highly stereoselective hydrogenations-as key-steps in the total synthesis of statins

Statins are inhibitors of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase (HMG-CoA reductase) and became the standard of care for treatment of hypercholesterolemia because of their efficacy, safety, and long-term benefits. They are administered as diaste

METHOD FOR THE PRODUCTION OF STATINS

The invention relates to a method for producing statins known as HMG-CoA reductase inhibitors. Some of the intermediate compounds used in the inventive method are novel compounds. The invention also relates to said novel intermediate compounds.

MEVINIC ACIDS AND ANALOGUES: PREPARATION OF A KEY CHIRAL INTERMEDIATE

The preparation of methyl 3-O-tert-butyldiphenylsilyl-2,4-dideoxy-β-D-erytrohexopyranoside, a key chiral intermediate for mevinic acids, and its elaboration into four mevinate analogues are described.