86031-24-5

Usage

Uses

Used in Biochemistry and Molecular Biology:
Hydroxylamine, O-[(1,1-dimethylethoxy)carbonyl]-, is used as a reactant in the PEGylation and dimerization of expressed proteins. This process allows for the attachment of polyethylene glycol (PEG) chains to proteins, enhancing their stability, solubility, and circulation time in biological systems. PEGylation is particularly useful in the development of therapeutic proteins and drug delivery systems, as it can improve their pharmacokinetic properties and reduce immunogenicity.
Additionally, the compound can be employed in the dimerization of proteins, which may be useful for studying protein-protein interactions, developing novel biomaterials, or creating artificial enzymes with enhanced catalytic properties.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 174138-01-3 1,4-di-tert-butyl 1,4,7-triazonane-1,4-dicarboxylate 
• 1301740-32-8 1-(o-phthalimidoxylyl)-4,7-bis(tert-butoxycarbonyl)-1,4,7-triazacyclononane 
• 1301740-40-8 1-{p-[bis(tert-butoxycarbonyl)guanidino]xylyl}-4,7-bis(tert-butoxycarbonyl)-1,4,7-triazacyclononane 
• 1301740-39-5 1-{m-[bis(tert-butoxycarbonyl)guanidino]xylyl}-4,7-bis(tert-butoxycarbonyl)-1,4,7-triazacyclononane 
• 1301740-38-4 1-{o-[bis(tert-butoxycarbonyl)guanidino]xylyl}-4,7-bis(tert-butoxycarbonyl)-1,4,7-triazacyclononane 
• 1301740-37-3 1-(p-aminoxylyl)-4,7-bis(tert-butoxycarbonyl)-1,4,7-triazacyclononane 
• 1301740-36-2 1-(m-aminoxylyl)-4,7-bis(tert-butoxycarbonyl)-1,4,7-triazacyclononane 
• 1301740-35-1 1-(o-aminoxylyl)-4,7-bis(tert-butoxycarbonyl)-1,4,7-triazacyclononane 
• 1301740-34-0 1-(p-phthalimidoxylyl)-4,7-bis(tert-butoxycarbonyl)-1,4,7-triazacyclononane 
• 1301740-33-9 1-(m-phthalimidoxylyl)-4,7-bis(tert-butoxycarbonyl)-1,4,7-triazacyclononane 
• 936576-80-6 1-(tert-butyloxycarbamido)-4-[2,3-di(isopropylmercapto)benzamido]benzene 
• 936576-77-1 1-(tert-butyloxycarbamido)-2-[2,3-di(isopropylmercapto)benzamido]benzene 
• 146651-75-4 tert–butyl (2–aminophenyl)carbamate 
• 71026-66-9 N-(tert-butoxycarbonyl)-1,4-phenylenediamine 

Relevant academic research and scientific papers

SYNTHESIS OF tert-BUTYL AMINOCARBONATE, A NEW TYPE OF COMPOUND THAT CAN BE USED TO ACYLATE AMINES

tert-Butyl aminocarbonate (tert-butyloxycarbonyloxyamine) was prepared by reaction of hydroxylamine with excess di-tert-butyl dicarbonate.Amino carbonates have not previously been described.This compound rapidly acylates amines in both organic and aqueous solutions.

Enantioselective Aminohydroxylation of Styrenyl Olefins Catalyzed by an Engineered Hemoprotein

Chiral 1,2-amino alcohols are widely represented in biologically active compounds from neurotransmitters to antivirals. While many synthetic methods have been developed for accessing amino alcohols, the direct aminohydroxylation of alkenes to unprotected, enantioenriched amino alcohols remains a challenge. Using directed evolution, we have engineered a hemoprotein biocatalyst based on a thermostable cytochrome c that directly transforms alkenes to amino alcohols with high enantioselectivity (up to 2500 TTN and 90 % ee) under anaerobic conditions with O-pivaloylhydroxylamine as an aminating reagent. The reaction is proposed to proceed via a reactive iron-nitrogen species generated in the enzyme active site, enabling tuning of the catalyst's activity and selectivity by protein engineering.

Sodium channel drugs and uses

The compounds of this invention comprise 2-10 ligands covalently connected, each of the ligands being capable of binding to a ligand binding site in a Na+channel, thereby modulating the biological activities thereof.

Synthesis of chiral isoxazolidin-5-ones and their applications to the synthesis of β-amino-alanines and β-(N-hydroxyamino)-alanines

Herein we report a high-yielding synthesis of isoxazolidin-5-ones and their use to synthesise both β-amino-alanines and β-(N-hydroxyamino)-alanines.