86031-55-2Relevant academic research and scientific papers
Horner-Wittig Reactions of β-Aminoalkyl- and β-N-Acylaminoalkyldiphenylphosphine Oxides: Synthesis of N-Allyl Amines and Amides and 5-Diphenylphosphinoyl-2-phenyl-5,6-dihydro-4H-1,3-oxazines
Cavalla, David,Cruse, William B.,Warren, Stuart
, p. 1883 - 1898 (2007/10/02)
Lithium derivatives of β-diphenylphosphinoyl-alkyl amines and dilithium derivatives of the corresponding amides combine with aldehydes or ketones in the Horner-Wittig reaction.Separation of the diastereoisomeric intermediates leads to single positional and geometrical isomers of N-allyl amines and amides.Attempted rearrangement of the same intermediates in acid solution gives dihydro-oxazines or, in one cases, a γ-N-acylaminoallyl diphenylphosphine oxide.
REGIO- AND STEREOSPECIFIC SYNTHESIS OF N-ALLYL AMIDES BY THE HORNER-WITTIG REACTION
Cavalla, David,Warren, Stuart
, p. 295 - 298 (2007/10/02)
E and Z allyl amides are formed with full regio- and stereochemical control from dianions of β-(acylamino)alkylphosphine oxides by the Horner-Wittig reaction.
