860436-54-0

Usage

Type of compound

chemical compound, hydrochloride salt of a psychoactive compound

Class

benzazepine

Structural relation

related to the neurotransmitter dopamine

Pharmacological effects

stimulates locomotion, anorexia and hyperactivity in animals

Potential use

treatment of central nervous system disorders, including Parkinson's disease and psychiatric conditions

Interest

subject of interest in neuroscience research and drug development.

Upstream product

• 72584-69-1 7,8-dimethoxy-2,3,4,5-tetrahydro-1H-benzo[c]azepin-1-one 
• 2107-70-2 3,4-methoxycinnamic acid 
• 27798-73-8 methyl 3-(3,4-dimethoxyphenyl)propionate 
• 14773-41-2 3-(3,4-dimethoxyphenyl)propionic acid amide 
• 14773-42-3 3-(3,4-dimethoxyphenyl)propylamine 
• 113193-85-4 N-acetyl-3-(3',4'-dimethoxyphenyl)-propylamine 

Relevant academic research and scientific papers

7. 8 - dimethoxy - 2, 3, 4, 5 - tetrahydro - 1 H - benzo [c] azepine hydrochloride and its preparation method (by machine translation)

The invention discloses 7, 8 - dimethoxy - 2, 3, 4, 5 - tetrahydro - 1 H - benzo [c] azepine hydrochloride and its preparation method, in order to 3, 4 - dimethoxy c acid as initiator, in thionyl chloride catalytic, then ammonolysis to obtain 3, 4 - dimet

SAR studies of capsazepinoid bronchodilators. Part 1: The importance of the catechol moiety and aspects of the B-ring structure

Capsazepine as well as its derivatives and analogues are general inhibitors of constriction of human small airways. From a systematic variation of the capsazepine structure, divided into four regions, SARs were established. This part concerns the catechol moiety of the A-ring as well as the 2,3,4,5-tetrahydro-1H-2-azepine moiety (the B-ring) of capsazepine. It is revealed that a conformational constrain (as a fused ring) is important and that compounds with a six-membered B-ring (as a 1,2,3,4-tetrahydroisoquinoline) in general are more potent than the corresponding isoindoline, 2,3,4,5-tetrahydro-1H-2-benzazepine and 2,3,4,5-tetrahydro-1H-3-benzazepine derivatives.

Bronchorelaxing compounds

A compound of the general formula (I) including its pharmaceutically acceptable acid addition salts wherein A is CHR9, wherein R9 is H, C1-C6 alkyl; n is 1-3; B is CHR10, wherein R10 is H, C1-C6 alkyl; m is 1 or 2; D is O or S or optionally NR16, wherein R16 is H, C1-C6 alkyl or C2-C6 acyl; E is CR11R12 or NR13, wherein R11 and R12 are, independent of each other, H or C1-C6 alkyl, R13 is H or C1-C6 alkyl; F is C1-C18 alkyl which may be mono- or di-unsaturated and/or substituted, is useful in treating and preventing pulmonary disease characterized by bronchoconstriction. Also disclosed are pharmaceutical compositions comprising the compound and methods for their manufacture.