86045-82-1Relevant articles and documents
Design, synthesis and bioevalucation of novel 2,3-dihydro-1H-inden-1-amine derivatives as potent and selective human monoamine oxidase B inhibitors based on rasagiline
Xiao, Xuan,Zhang, Xing-Xing,Zhan, Mei-Miao,Cheng, Kai,Li, Shiyu,Xie, Zhouling,Liao, Chenzhong
, p. 588 - 593 (2018)
Parkinson's disease (PD) is associated with elevated levels of hMAO-B in the brain, and MAO-B has been recognized a successful target for developing anti-PD drugs. Herein we report rasagiline derivatives as novel potent and selective hMAO-B inhibitors. Th
Indane derivative and synthetic method and medicinal application thereof
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Paragraph 0067; 0068; 0069; 0070, (2017/09/02)
The invention discloses an indane derivative and a synthetic method and medicinal application thereof. The structural general formula is as shown in the specification. The indane derivative disclosed by the invention has excellent inhibitory activity and high selectivity on MAO-B.
NOVEL TRICYCLIC CALCIUM SENSING RECEPTOR ANTAGONISTS
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, (2015/07/07)
Novel tricyclic compounds of Formula (I) and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing osteoporosis and similar conditions. The compounds are effective as calcium sensing receptor antagonists. Pharmaceutical compositions and methods of treatment are also included.