860505-23-3Relevant academic research and scientific papers
Chemistry of platensimycin
Singh, Sheo B.,Herath, Kithsiri B.,Wang, Jun,Tsou, Nancy,Ball, Richard G.
, p. 5429 - 5433 (2007)
Platensimycin is a novel natural product antibiotic that inhibits bacterial growth by inhibiting fatty acid synthesis specifically inhibiting the elongation condensing enzyme FabF. Reaction with diazomethane at controlled temperatures led to selective met
Total synthesis of (±)-platencin
Hayashida, Joji,Rawal, Viresh H.
supporting information; experimental part, p. 4373 - 4376 (2009/02/08)
(Chemical Equation Presented) Resistant bacteria - beware! Platencin, a structurally novel broad-spectrum antibacterial agent, was the target of a total synthesis from o-anisic acid (see scheme). A Diels-Alder reaction with an a-substituted cyclohexenone as well as a [Ni-(cod)2]-promoted 1,4-addition enables the concise and stereocontrolled formation of the core. A protecting group free coupling with an aniline unit completed the synthesis. cod = 1,5-cyclooctadiene.
