860638-34-2Relevant academic research and scientific papers
Novel phosphoramidate prodrugs of N-acetyl-(d)-glucosamine with antidegenerative activity on bovine and human cartilage explants
Serpi, Michaela,Bibbo, Rita,Rat, Stephanie,Roberts, Helen,Hughes, Claire,Caterson, Bruce,Alcaraz, María José,Gibert, Anna Torrent,Verson, Carlos Raul Alaez,McGuigan, Christopher
supporting information; experimental part, p. 4629 - 4639 (2012/07/01)
(d)-Glucosamine and other nutritional supplements have emerged as safe alternative therapies for osteoarthritis (OA), a chronic and degenerative articular joint disease. In our preceding paper, a series of novel O-6 phosphate N-acetyl (d)-glucosamine prod
Phosphate prodrugs derived from N-acetylglucosamine have enhanced chondroprotective activity in explant cultures and represent a new lead in antiosteoarthritis drug discovery
McGuigan, Christopher,Serpi, Michaela,Bibbo, Rita,Roberts, Helen,Hughes, Clare,Caterson, Bruce,Gibert, Ana Torrent,Verson, Carlos Raúl Alaez
experimental part, p. 5807 - 5812 (2009/09/06)
We report the application of the phosphoramidate ProTide approach, developed by us for antiviral nucleosides, to sugar derivatives with potential chondroprotection against osteoarthritis. In particular, N-acetylglucosamine was converted to a series of 06
PHOSPHORAMIDATE DERIVATIVES
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Page/Page column 25-26, (2008/06/13)
The present invention provides a phosphoramidate compound comprising the structure (I) Formula (I)wherein: X comprises a monosaccharide group comprising the structure (II) or (III),8Formula (II) , (III) B and B are independently selected from the group co
