5557-81-3

Basic information

• Product Name: alanine benzyl ester hydrochloride
• CAS NO: 5557-81-3
• Molecular Weight: 215.68
• Mol File: 5557-81-3.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: alanine benzyl ester hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: alanine benzyl ester hydrochloride(5557-81-3)
• EPA Substance Registry System: alanine benzyl ester hydrochloride(5557-81-3)

Safety Data

• Hazardous Substances Data: 5557-81-3(Hazardous Substances Data)

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 56-41-7 L-alanin 
• 100-51-6 benzyl alcohol 
• 126400-95-1 N-(tert-butoxycarbonyl)-L-alanine benzyl ester 
• 100-39-0 benzyl bromide 
• 3744-87-4 N-t-butyloxycarbonyl-DL-alanine 
• 338-69-2 D-Alanine 
• 15761-38-3 L-N-Boc-Ala 
• 100-44-7 benzyl chloride 
• 126400-95-1 N-(tert-butoxycarbonyl)alanine benzyl ester 

Downstream Products

• 66415-01-8 N-((tert-butoxycarbonyl)-L-leucyl)-L-alanine benzyl ester 
• 114285-13-1 DL-N-acetylamino alanine benzyl ester 
• 118234-89-2 Z-(S)-Val-(S)-Ala-OBzl 
• 126496-70-6 N^α-(t-butoxycarbonyl)-O-(benzyl)threonylalanine benzyl ester 
• 671753-67-6 (S)-2-(2-pent-4-enyl-hept-6-enoylamino)propionic acid benzyl ester 
• 203636-23-1 (S)-2-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-methyl-propionylamino]-propionic acid benzyl ester 
• 96467-84-4 N-(O-benzyl-N-benzyloxycarbonyl-L-α-glutamyl)-L-alanine benzyl ester 
• 935887-90-4 C₁₉H₂₈N₂O₆ 
• 173918-06-4 L-O-leucine-D-alanine benzyl ester 
• 1189526-24-6 L-O-lysine(Boc)-D-alanine benzyl ester 

Relevant articles and documents

N-transfer reagent and method for preparing the same and its application

Provided are a novel N-transfer reagent and a method for preparing the same and its application. The N-transfer reagent is represented by the following Formula (I): The various novel N-transfer reagents of the present invention can be quickly prepared by employing different nitrobenzene precursors. The N-transfer reagents can directly convert a variety of amino compounds into diazo compounds under mild conditions. Particularly, the N-transfer reagents can facilitate the synthesis of the diazo compounds. The application of synthesizing diazo compounds of the present invention can greatly decrease the difficulty in operation, increase the safety during experiments, reduce the cost of production and the environmental pollution, and enhance the industrial value of diazo compounds.

Identification of a 4-fluorobenzyl L-valinate amide benzoxaborole (AN11736) as a potential development candidate for the treatment of Animal African Trypanosomiasis (AAT)

Novel L-valinate amide benzoxaboroles and analogues were designed and synthesized for a structure-activity-relationship (SAR) investigation to optimize the growth inhibitory activity against Trypanosoma congolense (T. congolense) and Trypanosoma vivax (T. vivax) parasites. The study identified 4-fluorobenzyl (1-hydroxy-7-methyl-1,3-dihydrobenzo[c][1,2]oxaborole-6-carbonyl)-L-valinate (5, AN11736), which showed IC50 values of 0.15 nM against T. congolense and 1.3 nM against T. vivax, and demonstrated 100% efficacy with a single dose of 10 mg/kg against both T. congolense and T. vivax in mouse models of infection (IP dosing) and in the target animal, cattle, dosed intramuscularly. AN11736 has been advanced to early development studies.

Discovery of 2'-α-C-Methyl-2'-β-C-fluorouridine Phosphoramidate Prodrugs as Inhibitors of Hepatitis C Virus

2′-α-C-Methyl-2′-β-C-fluorouridine and its phosphoramidate prodrugs were synthesized and evaluated for their inhibitory activity against HCV. The structure?activity relationship analysis of the phosphoramidate moiety found that 17m, 17q, and 17r exhibit potent activities against HCV, with EC50 values of 1.82 ± 0.19, 0.88 ± 0.12, and 2.24 ± 0.22 μM, respectively. The docking study revealed that the recognition of the 2′-β-F by Arg158, 3′-OH by N291, and the Watson?Crick pairing with the template allowed 23 to form the in-line conformation necessary for its incorporation into the viral RNA chain.