860802-44-4Relevant academic research and scientific papers
Molecular modeling, design, and synthesis of less lipophilic derivatives of 3-(4-tetradecyloxybenzyl)-4H-1,2,4-oxadiazol-5-one (PMS1062) specific for group II enzyme
Plocki, Stephanie,Aoun, Darina,Ahamada-Himidi, Azali,Tavares-Camarinha, Fernanda,Dong, Chang-Zhi,Massicot, France,Huet, Jack,Adolphe-Pierre, Sylvie,Chau, Francois,Godfroid, Jean-Jacques,Gresh, Nohad,Ombetta, Jean Edouard,Heymans, Francoise
, p. 2747 - 2757 (2005)
3-(4-Tetradecyloxybenzyl)-4H-1,2,4-oxadiazol-5-one(PMS1062 or I) can probably act as a PLA2-II inhibitor on the acute inflammation model, but its highly lipophilic character could prevent it from being biodistributed effectively. In this work,
