Molecular modeling, design, and synthesis of less lipophilic derivatives of 3-(4-tetradecyloxybenzyl)-4H-1,2,4-oxadiazol-5-one (PMS1062) specific for group II enzyme

Article abstract of DOI:10.1002/ejoc.200400541

3-(4-Tetradecyloxybenzyl)-4H-1,2,4-oxadiazol-5-one(PMS1062 or I) can probably act as a PLA₂-II inhibitor on the acute inflammation model, but its highly lipophilic character could prevent it from being biodistributed effectively. In this work,