860994-80-5

Basic information

• Product Name: Thiourea, N-[(1R,2R)-2-(dimethylamino)cyclohexyl]-N'-[(1S)-1-phenylethyl]-
• CAS NO: 860994-80-5
• Molecular Formula: C17H27N3S
• Molecular Weight: 305.487
• Mol File: 860994-80-5.mol

Chemical Properties

• CAS DataBase Reference: Thiourea, N-[(1R,2R)-2-(dimethylamino)cyclohexyl]-N'-[(1S)-1-phenylethyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Thiourea, N-[(1R,2R)-2-(dimethylamino)cyclohexyl]-N'-[(1S)-1-phenylethyl]-(860994-80-5)
• EPA Substance Registry System: Thiourea, N-[(1R,2R)-2-(dimethylamino)cyclohexyl]-N'-[(1S)-1-phenylethyl]-(860994-80-5)

Safety Data

• Hazardous Substances Data: 860994-80-5(Hazardous Substances Data)

Upstream product

• 1020665-66-0 (1R,2R)-2-isothiocyanato-N,N-dimethylcyclohexanamine 
• 2627-86-3 (S)-1-phenyl-ethylamine 

Relevant articles and documents

Fine-tunable organocatalysts bearing multiple hydrogen-bonding donors for construction of adjacent quaternary and tertiary stereocenters via a michael reaction

The fine-tunable bifunctional amine/thiourea organocatalysts, relying on multipe hydrogen-bonding donors was investigated. A representative set of aryl and alkyl substituted nitroolefins were surveyed under the optimal experimental conditions. The trisubstituted carbon nucleophiles were examined with a 10 mol% of catalyst. The significant role of the multiple hydrogen-bonding donors played in the system was demonstrated through the control experiments using less bulky methylated (1R,2R,1'R,2'R)-II-E, (1R,2R,S)-II-F, and (1R,2R,R)-II-G as the catalyst under the optimized reaction condition. The fine tunable amine/thiourea organocatalysts, relying on multiple hydrogen-binding donors, showed excellent activity, diastereoselectivity, enantioselectivity, and structural scope in asymmetric Michael addition of α-substituted β-ketoesters to nitroolefins.