86100-10-9

Basic information

• Product Name: 8-chloro-3-methyl-2-phenylchromeno[4,3-c]pyrazol-4(2H)-one
• CAS NO: 86100-10-9
• Molecular Formula: C₁₇H₁₁ClN₂O₂
• Molecular Weight: 310.7344
• Mol File: 86100-10-9.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 508.9°C at 760 mmHg
• Flash Point: 261.6°C
• Density: 1.41g/cm³
• Vapor Pressure: 1.78E-10mmHg at 25°C
• Refractive Index: 1.693
• CAS DataBase Reference: 8-chloro-3-methyl-2-phenylchromeno[4,3-c]pyrazol-4(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 8-chloro-3-methyl-2-phenylchromeno[4,3-c]pyrazol-4(2H)-one(86100-10-9)
• EPA Substance Registry System: 8-chloro-3-methyl-2-phenylchromeno[4,3-c]pyrazol-4(2H)-one(86100-10-9)

Safety Data

• Hazardous Substances Data: 86100-10-9(Hazardous Substances Data)

Upstream product

• 100-63-0 phenylhydrazine 
• 97783-06-7 C₁₃H₁₁ClN₂O 
• 141-97-9 ethyl acetoacetate 
• 59-88-1 phenylhydrazine hydrochloride 
• 86100-03-0 6-Chloro-4-hydroxy-3-[1-(phenyl-hydrazono)-ethyl]-chromen-2-one 

Relevant articles and documents

La(OTf)3 catalyzed reaction of salicylaldehyde phenylhydrazones with β-ketoesters and activated alkynes: Facile approach for the preparation of chromenopyrazolones

A facile approach has been developed for the preparation of chromenopyrazolones (5a-o, 7a-k) by the reaction of salicylaldehyde phenylhydrazones (3a-o) with β-ketoesters (4a, 4f-g) and activated alkynes (6a-e) in the presence of La(OTf)3 with good yields. However, the reaction of salicylaldehyde phenylhydrazones (3a, 3c, 3j-k, 3n) with ethyl 4-chloro-3-oxobutanoate (4e) underwent cyclization with reductive dechlorination and provided the methyl chromenopyrazolones instead of chloromethyl chromenopyrazolones. The present solvent free protocol provided the novel heterocyclic compounds.