861063-50-5Relevant academic research and scientific papers
Phenylpyrazolo[1,5-a]quinazolin-5(4 H)-one: A suitable scaffold for the development of noncamptothecin topoisomerase i (Top1) inhibitors
Taliani, Sabrina,Pugliesi, Isabella,Barresi, Elisabetta,Salerno, Silvia,Marchand, Christophe,Agama, Keli,Simorini, Francesca,La Motta, Concettina,Marini, Anna Maria,Di Leva, Francesco Saverio,Marinelli, Luciana,Cosconati, Sandro,Novellino, Ettore,Pommier, Yves,Di Santo, Roberto,Da Settimo, Federico
supporting information, p. 7458 - 7462 (2013/10/21)
In search for a novel chemotype to develop topoisomerase I (Top1) inhibitors, the pyrazolo[1,5-a]quinazoline nucleus, structurally related to the indenoisoquinoline system precursor of well-known Top1 poisons, was variously decorated (i.e., a substituted
