861145-19-9Relevant academic research and scientific papers
Catalytic synthesis of γ-lactams via direct annulations of enals and N-sulfonylimines
He, Ming,Bode, Jeffrey W.
, p. 3131 - 3134 (2005)
(Chemical Equation Presented) Cinnamaldehydes and N-sulfonylimines undergo direct annulations to cis-disubstituted γ-lactams via the intermediacy of catalytically generated homoenolates. Critical to the success of this process was overcoming inhibition of the N-heterocyclic carbene catalyst by the electrophilic imines. The overall process proceeds with good yields and diastereoselectivites and requires no stoichiometric reagents or additives.
