3395-83-3

Basic information

• Product Name: p-(dimethoxymethyl)toluene
• Synonyms: p-(dimethoxymethyl)toluene;p-(Dimethoxymethyl)toluol;1-(Dimethoxymethyl)-4-methylbenzene;1-Dimethoxymethyl-4-methylbenzene;p-Methylbenzaldehyde dimethyl acetal;p-Tolualdehyde dimethyl acetal;Benzene, 1-(dimethoxymethyl)-4-methyl-;Einecs 222-244-9
• CAS NO: 3395-83-3
• Molecular Formula: C₁₀H₁₄O₂
• Molecular Weight: 166.21696
• EINECS: 222-244-9
• Mol File: 3395-83-3.mol
• Article Data: 68

Chemical Properties

• Boiling Point: 196.2°Cat760mmHg
• Flash Point: 58.4°C
• Appearance: /
• Density: 0.986g/cm³
• Vapor Pressure: 0.567mmHg at 25°C
• Refractive Index: 1.49
• CAS DataBase Reference: p-(dimethoxymethyl)toluene(CAS DataBase Reference)
• NIST Chemistry Reference: p-(dimethoxymethyl)toluene(3395-83-3)
• EPA Substance Registry System: p-(dimethoxymethyl)toluene(3395-83-3)

Safety Data

• Hazardous Substances Data: 3395-83-3(Hazardous Substances Data)

Usage

General Description

p-(dimethoxymethyl)toluene is a chemical compound with the molecular formula C9H12O2. It is a derivative of toluene, with the methoxy group attached to the para position of the benzene ring and the methoxymethyl group attached to the methyl group of toluene. p-(dimethoxymethyl)toluene is often used in the production of fragrances and flavorings due to its aromatic properties. It can also be utilized as a solvent and an intermediate in the synthesis of other organic compounds. Additionally, p-(dimethoxymethyl)toluene has potential applications in the pharmaceutical and cosmetic industries. However, it is important to handle this chemical with care as it may have health and environmental hazards if not properly managed.

InChI:InChI=1/C10H14O2/c1-8-4-6-9(7-5-8)10(11-2)12-3/h4-7,10H,1-3H3

Upstream product

• 616-42-2 dimethylsulfite 
• 104-87-0 4-methyl-benzaldehyde 
• 67-56-1 methanol 
• 7450-04-6 1-((trimethylsilyl)methyl)-4-methylbenzene 
• 106-42-3 para-xylene 
• 622-97-9 1-ethenyl-4-methylbenzene 
• 149-73-5 trimethyl orthoformate 
• 3395-81-1 4-chlorobenzaldehyde dimethyl acetal 
• 74-88-4 methyl iodide 
• 124-41-4 sodium methylate 
• 2698-14-8 1-methyl-4-(prop-1-enyl)benzene 
• 35779-32-9 1,3,5-tris(4-methylphenyl)-2,4-diazapenta-1,4-diene 

Downstream Products

• 22911-22-4 1-methyl-4-(trimethoxymethyl)benzene 
• 93943-06-7 4-(methoxymethyl)benzaldehyde 
• 623-27-8 terephthalaldehyde, 
• 1571-08-0 methyl 4-formylbenzoate 
• 87505-91-7 2-<(4-methylphenyl)methoxymethyl>-2-(trimethylsiloxy)cyclobutanone 
• 536-50-5 CH₃C₆H₄CH(CH₃)OH 
• 104-87-0 4-methyl-benzaldehyde 
• 911798-06-6 meso-1,2-bis-(4-dimethylphenyl)-1,2-dimethoxyethane 
• 89986-85-6 1,2-dimethoxy-1,2-di(4-methylphenyl)ethane 
• 104-82-5 4-Methylbenzyl chloride 
• 104-81-4 4-Methylbenzyl bromide 
• 99-75-2 4-methyl-benzoic acid methyl ester 
• 5558-02-1 4-methoxy-1,1-diphenyl-1-butene 
• 219518-19-1 4-methylphenyl 4,6-O-benzylidene-1-thio-β-D-glucopyranoside 

Relevant articles and documents

Electrochemical Obtention of cis- and trans-3,6-Dimethoxy-3,6-dimethyl-1,4-cyclohexadienes

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Thiol-initiated photocatalytic oxidative cleavage of the C=C bond in olefins and its extension to direct production of acetals from olefins

The oxidative cleavage of olefins to produce aldehydes/ketones is an important reaction in organic syntheses. In this manuscript, a mild and operationally simple protocol for the aerobic oxidation of olefins to produce carbonyl compounds was realized over ZnIn2S4under visible light, using air as the oxidant and a thiol as the initiator. It was proposed that the photogenerated holes over ZnIn2S4attack the thiol to produce thiyl radicals, which initiate the oxidative cleavage of the C=C bond in olefins to produce aldehydes/ketones. By further coupling with the condensation between the as-obtained aldehydes/ketones and alcohols, this strategy can also be applied to the production of different acetals directly from the olefins. This study demonstrates a new pathway to realize the oxidative cleavage of olefins to produce aldehydes/ketones, and also provides a new protocol for the production of acetals directly from the olefins.

Enantioselective, Catalytic Multicomponent Synthesis of Homoallylic Amines Enabled by Hydrogen-Bonding and Dispersive Interactions

We report a one-step catalytic, enantioselective method for the preparation of homoallylic N-Boc amines directly from acetals. Reactive iminium ion intermediates are generated in situ through the combination of an acetal, a chiral thiourea catalyst, trialkylsilyl triflate, and N-Boc carbamate and are subsequently trapped by a variety of allylsilane nucleophiles. No homoallylic ether byproducts are detected, consistent with allylation of the iminium intermediate being highly favored over allylation of the intermediate oxocarbenium ion. Acetals derived from aromatic aldehydes possessing a variety of functional groups and substitution patterns yield homoallylic amines with excellent levels of enantiomeric enrichment. Experimental and computational data are consistent with an anchoring hydrogen-bond interaction between the protioiminium ion and the amide of the catalyst in the enantiodetermining transition state, and with stereodifferentiation achieved through specific noncovalent interactions (NCIs) with the catalyst pyrenyl moiety. Evidence is provided that the key NCI in the major pathway is a π-stacking interaction, contrasting with the cation-πinteractions invoked in previously studied reactions promoted by the same family of aryl-pyrrolidino-H-bond-donor catalysts.