86116-17-8

Upstream product

• 28170-13-0 thiobenzoic acid potassium salt 
• 106-96-7 propargyl bromide 
• 624-65-7 2-propynyl chloride 
• 27846-30-6 prop-2-yn-1-thiol 
• 98-88-4 benzoyl chloride 
• 80357-05-7 1,2-benzisothiazol-3-(2H)-thione-1,1-dioxide nitranion sodium salt 
• 93-97-0 benzoic acid anhydride 
• 37671-90-2 3-Prop-2-ynylsulfanyl-benzo[d]isothiazole 1,1-dioxide 

Downstream Products

• 455-32-3 benzoyl fluoride 
• 1610541-80-4 C₁₉H₂₁N₂O₁₅P₃S 
• 172531-42-9 5-(3-benzoylthiopropyn-1-yl)-2'-deoxyuridine 
• 1610541-98-4 C₁₉H₁₉N₃O₅S 
• 1610541-99-5 C₁₉H₂₂N₃O₁₄P₃S 

Relevant academic research and scientific papers

One-pot synthesis of thioesters with sodium thiosulfate as a sulfur surrogate under transition metal-free conditions

In this paper, we report an efficient synthetic method for thioester formation from sodium thiosulfate pentahydrate, organic halides, and aryl anhydrides. In the one-pot two-step reactions developed in this study, sodium thiosulfate was used as the sulfur surrogate for acylation with anhydrides, followed by substitution with organic halides through the in situ generation of thioaroylate. Furthermore, two important organic compounds could be successfully synthesized using our developed method. The advantages of the one-pot two-step reactions are operational simplicity, structurally diverse products with 42%-90% yields, use of relatively low toxic and odourless reagents, and easy applicability to large-scale operation.

One-pot odourless synthesis of thioesters via in situ generation of thiobenzoic acids using benzoic anhydrides and thiourea

An efficient and odourless procedure for a one-pot synthesis of thioesters by the reaction of benzoic anhydrides, thiourea and various organic halides (primary, allylic, and benzylic) or structurally diverse, electron-deficient alkenes (ketones, esters, and nitriles) in the presence of Et3 N has been developed. In this method, thiobenzoic acids were in situ generated from the reaction of thiourea with benzoic anhydrides, which were subjected to conjugate addition with electron-deficient alkenes or a nucleophilic displacement reaction with alkyl halides.

An odorless, one-pot synthesis of thioesters from organic halides, thiourea and benzoyl chlorides in water

Thioesterification can be realized via an odorless, one-pot reaction through the in situ generation of S-alkylisothiouronium salts from organic halides and thiourea in aqueous Triton X-100 (TX100) micelles. The protocol is free of foul-smell thiols and or

A convenient laboratory preparation of propargylthiol and its derivatives

Reduction of propargyl S-thioacetate, followed by elimination of excess hydride and acidification, constitutes a practical alternative for the preparation of propargylthiol (as a solution of easily determined concentration) or of its derivatives (by trapping the intermediate thiolate with a suitable electrophile).

An Odorless Preparative Method of Sulfides and Thiocarboxylic S-Esters Using 3-(Alkylthio)-1,2-benzisothiazole 1,1-Dioxide

It was found that sodium salt of 1,2-benzisothiazole-3(2H)-thione 1,1-dioxide (thiosaccharin) readily reacted with alkyl halide affording 3-(alkylthio)-1,2-benzisothiazole 1,1-dioxide (3).Treatment of 3 with piperidine produces the corresponding alkanethiol in situ quantitatively and subsequent treatment with various electrophiles gives the corresponding sulfides and thiocarboxylic S-esters in good yields.