861227-10-3Relevant academic research and scientific papers
Synthesis and biological evaluation of novel macrocyclic paclitaxel analogues
Metaferia, Belhu B.,Hoch, Jeannine,Glass, Thomas E.,Bane, Susan L.,Chatterjee, Sabarni K.,Snyder, James P.,Lakdawala, Ami,Cornett, Ben,Kingston, David G. I.
, p. 2461 - 2464 (2001)
matrix presented This work describes the synthesis of two novel macrocyclic taxoid constructs by ring-closing olefin metathesis (RCM) and their biological evaluation. Computational studies examine conformational profiles of 1 and 2 for their fit to the β-
CONFORMATIONALLY CONSTRAINED PACLITAXEL ANALOGS AND THEIR USE AS ANTICANCER AND ANTI-ALZHEIMERS AGENTS
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Page/Page column Fig. 3; 5, (2010/02/13)
Constrained paclitaxel derivatives include a bridge extending from the C-3’ phenyl to either the C4 or -3 positions. Many of the constrained paclitaxel derivatives provide activity comparable or superior to the natural product paclitaxel.
