360075-38-3Relevant articles and documents
Evaluation of the tubulin-bound paclitaxel conformation: Synthesis, biology, and SAR studies of C-4 to C-3′ bridged paclitaxel analogues
Ganesh, Thota,Yang, Chao,Norris, Andrew,Glass, Tom,Bane, Susan,Ravindra, Rudravajhala,Banerjee, Abhijit,Metaferia, Belhu,Thomas, Shala L.,Giannakakou, Paraskevi,Alcaraz, Ana A.,Lakdawala, Ami S.,Snyder, James P.,Kingston, David G. I.
, p. 713 - 725 (2007/10/03)
The important anticancer drug paclitaxel binds to the β-subunit of the ββ-tubulin dimer in the microtubule in a stoichiometric ratio, promoting microtubule polymerization and stability. The conformation of microtubule-bound drug has been the subject of in
CONFORMATIONALLY CONSTRAINED PACLITAXEL ANALOGS AND THEIR USE AS ANTICANCER AND ANTI-ALZHEIMERS AGENTS
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Page/Page column Fig. 3; 5, (2010/02/13)
Constrained paclitaxel derivatives include a bridge extending from the C-3’ phenyl to either the C4 or -3 positions. Many of the constrained paclitaxel derivatives provide activity comparable or superior to the natural product paclitaxel.
Synthesis and biological evaluation of novel macrocyclic paclitaxel analogues
Metaferia, Belhu B.,Hoch, Jeannine,Glass, Thomas E.,Bane, Susan L.,Chatterjee, Sabarni K.,Snyder, James P.,Lakdawala, Ami,Cornett, Ben,Kingston, David G. I.
, p. 2461 - 2464 (2007/10/03)
matrix presented This work describes the synthesis of two novel macrocyclic taxoid constructs by ring-closing olefin metathesis (RCM) and their biological evaluation. Computational studies examine conformational profiles of 1 and 2 for their fit to the β-
