861228-95-7

Upstream product

• 996-82-7 sodium diethylmalonate 
• 621-30-7 3-methylphenyl isothiocyanate 
• 105-53-3 diethyl malonate 
• 3288-02-6 diethyl (3-methylphenyl)thiocarbamoylmalonate 

Downstream Products

• 861228-97-9 ethyl 2-(benzothiazol-2-yl)-3-(3-methylphenyl)amino-5-oxo-2,5-dihydro-4-carboxylate 
• 1271133-42-6 ethyl 2-(benzo[d]oxazol-2-yl)-5-oxo-3-(m-tolylamino)-2,5-dihydroisoxazole-4-carboxylate 
• 1271133-88-0 ethyl 2-(m-tolylamino)imidazo[1,2-a]pyrimidine-3-carboxylate 
• 874179-48-3 ethyl 3-(3-methylphenyl)amino-2-(5-nitropyrid-2-yl)-5-oxo-2,5-dihydroisoxazole-4-carboxylate 
• 874179-52-9 ethyl 2-(3-methylphenyl)amino-6-nitroimidazo[1,2-a]pyridine-3-carboxylate 
• 1404420-21-8 ethyl 4-chloro-2-(m-tolylamino)imidazo[1,2-a]quinoxaline-1-carboxylate 
• 1404420-17-2 diethyl 2,11-bis(m-tolylamino)diimidazo[1,2-a:2',1'-c]quinoxaline-3,10-dicarboxylate 
• 1404420-18-3 ethyl 2-(3-chloroquinoxalin-2-yl)-5-oxo-3-(m-tolylamino)-2,5-dihydroisoxazole-4-carboxylate 
• 1334232-61-9 8-methyl-3-(3-methylphenyl)-1H-azeto[2',1':2,3]pyrimido[4,5-b]quinoline-1,4(3H)-dione 
• 1334232-56-2 7-methyl-3-(3-methylphenyl)-1H-azeto[2',1':2,3]pyrimido[4,5-b]quinoline-1,4(3H)-dione 
• 1334232-51-7 3-(3-methylphenyl)-1H-azeto[2',1':2,3]pyrimido[4,5-b]quinoline-1,4(3H)-dione 
• 1271133-58-4 ethyl 5-oxo-2-(pyrimidin-2-yl)-3-(m-tolylamino)-2,5-dihydroisoxazole-4-carboxylate 

Relevant academic research and scientific papers

Rearrangements of 2-pyridyl-3-arylaminoisoxazol-5(2H)-ones to imidazo[1,2-a]pyridines under flash-vacuum-pyrolysis

2-Pyridyl-3-arylaminoisoxazol-5(2H)-ones, rearranged under flash-vacuum-pyrolysis (FVP) conditions accompanied by elimination of carbon dioxide to give imidazo[1,2-a]pyridines in high to excellent yields (85-95 %).

Ethyl 5-oxo-3-arylamino-2,5-dihydroisoxazole-4-carboxylates as sources of imidazopyrimidine and aminoindole derivatives

The reaction of ethyl 5-oxo-3-arylamino-2,5-dihydroisoxazole-4-carboxylates with 2-chloropyrimidine and 2-chlorobenzoxazole gave the corresponding isoxazolones with pyrimidine and benzoxazole rings substituted on N-2. Their rearrangements with triethylamine in ethanol produced the corresponding imidazopyrimidine and aminoindole derivatives, respectively, through intramolecular cyclisation. TUeBITAK.

Synthesis of ethyl 2-arylaminoimidazo[2,1-b]benzothiazole-3-carboxylates

3-Arylamino-4-ethoxycarbonylisoxazol-5(2H)-ones, substituted on nitrogen with a benzothiazole group, reacts with triethylamine in ethanol under reflux conditions to provide a convenient synthesis of ethyl 2-arylaminoimidazo[2,1-b] benzothiazole-3-carboxyl