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Usage

Type of compound

Dicarboxylic acid derivative 2,2-bis(3-phenylpropyl) malonic acid is derived from a dicarboxylic acid, which means it contains two carboxyl (-COOH) groups.

Primary use

Intermediate in pharmaceutical and organic compound production It is mainly used as an intermediate substance in the synthesis of various pharmaceuticals and organic compounds.

Potential properties

Anti-inflammatory and anti-cancer Some reports suggest that this chemical may have potential anti-inflammatory and anti-cancer properties.

Physical appearance

White to light yellow crystalline powder The compound appears as a white to light yellow powder in its solid form.

Solubility

Sparingly soluble in water, readily soluble in organic solvents The compound does not dissolve well in water but dissolves easily in organic solvents.

Application

Used in various organic synthesis processes The compound is utilized in a wide range of organic synthesis processes for the production of different chemical substances.

Upstream product

• 637-59-2 1-Bromo-3-phenylpropane 
• 389827-35-4 bis-(3-phenyl-propyl)-malonic acid diethyl ester 

Downstream Products

• 145600-22-2 2,2-Bis-(3-phenyl-propyl)-N,N'-di-quinolin-8-yl-malonamide 
• 262608-65-1 5-phenyl-2-(3-phenyl-propyl)-valeric acid 

Relevant academic research and scientific papers

Synthesis, characterization and cytotoxicity of a carboxylic ligand 2,2-bis(3-phenylpropyl) malonic acid and a corresponding Mn(ii) complex

The organic ligand Hbpmc and the polymeric complex [Mn(bpmc) 2(4,4′-bipy)(H2O)2]n· 3H2O (4,4′-bipy = 4,4′-bipyridine, Hbpmc = 2,2-bis(3-phenylpropyl) malonic acid), which have both a lipophilic group (aromatic ring) and a hydrophilic group (non-coordination carboxyl), were synthesized and characterized by IR spectra, elemental analysis and X-ray single-crystal diffraction. The interaction of the complexes with HC-DNA was investigated by fluorescence spectroscopy. Gel electrophoresis assay demonstrates the ability to cleave the extracted HC-DNA. The value of IC 50 is to understand the effect of cytotoxic activity which is lower than cisplatin and higher than the ligand Hbpmc. The apoptotic tests show that the complexes apparently have an apoptotic effect on Hela cells.

Role of Substituents in Copper(II) Extraction with N,N'-Bis(8-quinolyl)malonamides

It has been found that substituents on N,N'-bis (8-quinolyl)malonamide play an important role in copper(II) extraction: among the substituents studied, benzyl groups dramatically increased extractability of the malonamide complex.The role of substituents is discussed on the basis of the results of titration and 1H NMR measurements of copper(II) or nickel(II) complexes as well as copper(II)-extraction experiments.Intramolecular interactions between ? electrons of the benzyl group and the metal centre of the complex are proposed to occur.