389827-35-4Relevant academic research and scientific papers
Synthesis, characterization and cytotoxicity of a carboxylic ligand 2,2-bis(3-phenylpropyl) malonic acid and a corresponding Mn(ii) complex
Zhu, Ming-Chang,Dai, Lei,Gao, En-Jun,Lin, Lin,Wang, Bo,Liu, Lei
, p. 13352 - 13358 (2013/01/15)
The organic ligand Hbpmc and the polymeric complex [Mn(bpmc) 2(4,4′-bipy)(H2O)2]n· 3H2O (4,4′-bipy = 4,4′-bipyridine, Hbpmc = 2,2-bis(3-phenylpropyl) malonic acid), which have both a lipophilic group (aromatic ring) and a hydrophilic group (non-coordination carboxyl), were synthesized and characterized by IR spectra, elemental analysis and X-ray single-crystal diffraction. The interaction of the complexes with HC-DNA was investigated by fluorescence spectroscopy. Gel electrophoresis assay demonstrates the ability to cleave the extracted HC-DNA. The value of IC 50 is to understand the effect of cytotoxic activity which is lower than cisplatin and higher than the ligand Hbpmc. The apoptotic tests show that the complexes apparently have an apoptotic effect on Hela cells.
Role of Substituents in Copper(II) Extraction with N,N'-Bis(8-quinolyl)malonamides
Hirose, Takuji,Hiratani, Kazuhisa,Kasuga, Kazuyuki,Saito, Kiyoshi,Koike, Tohru,et al.
, p. 2679 - 2684 (2007/10/02)
It has been found that substituents on N,N'-bis (8-quinolyl)malonamide play an important role in copper(II) extraction: among the substituents studied, benzyl groups dramatically increased extractability of the malonamide complex.The role of substituents is discussed on the basis of the results of titration and 1H NMR measurements of copper(II) or nickel(II) complexes as well as copper(II)-extraction experiments.Intramolecular interactions between ? electrons of the benzyl group and the metal centre of the complex are proposed to occur.
