86134-12-5Relevant academic research and scientific papers
Synthesis and biological evaluation of imidazoline derivatives as potential CNS and CVS agents
Malhotra, Vineet,Vats, Monika,Nath, Rajendra,Mehta, Simpi,Kumar, Rakesh,Bhalla, Manish,Sinha,Shanker,Pathak, Seeema R.
, (2020)
A series of substituted imidazoline derivatives were synthesized and characterized. Compounds were tested in-vivo for their antihypertensive, analgesic, antiaggressive, depressant, antidepressant, and ALD50 activities. The compounds 3a, 3c, 4c, 5a, and 6c showed cardiovascular as well as central nervous system activities and are potential candidate as drug among all fifteen compounds tested. All these compounds have shown better activity for antihypertensive, analgesic, antiaggressive, and depressant-antidepressant, properties than reference compounds clonidine, morphine, diazepam, and imipramine respectively. Most of the compounds have shown ALD50 > 500 mg/kg with maximum in 4a and 5a (>1000 mg/kg).
Studies in potential filaricides: Part 23 - Synthesis of 1-substituted-4-benzylidene-2-methylimidazolin-5-ones as a new class of antifilarial agents
Srivastava, Ravi P,Singh, Sudhir K,Sharma, Satyavan,Singh, S N,Fatma, N,Chatterjee, R K
, p. 859 - 864 (2007/10/02)
1-Substituted-4-benzylidene-2-methylimidazolidin-5-ones (9-20) have been synthesized by treating 4-benzylidene-2-methyloxazolidin-5-one (2) and 4-(3,5-dichlorophenylbenzylidene)-2-methyloxazolidin-5-one (3) with respective amines.Reaction of 19 with alkyl
