86134-80-7

Upstream product

• 110-89-4 piperidine 
• 120096-84-6 1-amino-2-[3-(3-formylphenoxy)propylamino]-1-cyclobutene-3,4-dione 
• 1336-21-6 ammonium hydroxide 
• 120370-37-8 1-butoxy-2-[3-(3-piperidinomethylphenoxy)propylamino]-1-cyclobutene-3,4-dione 
• 73278-98-5 N-<3-<3-(1-piperidinylmethyl)phenoxy>propyl>amine 
• 5222-73-1 3,4-dimethoxy-3-cyclobutene-1,2-dione 
• 5231-88-9 1-Amino-2-methoxy-cyclobut-1-ene-3,4-dione 
• 120356-93-6 1-butoxy-2-(3-bromopropylamino)-1-cyclobutene-3,4-dione 
• 73279-04-6 3-[1-piperidinylmethyl]phenol 
• 100-83-4 meta-hydroxybenzaldehyde 

Relevant academic research and scientific papers

SUBSTITUTED 3-CYCLOBUTENE-1,2-DIONE INTERMEDIATES

The present invention relates to novel intermediates of the formula STR1 wherein R is lower alkyl or cyclohexyl, and X is hydroxy or a conventional leaving group, and the use thereof in a process for the preparation of certain histamine H 2-antagonists.

CHEMICAL INTERMEDIATES AND PROCESS

The present invention relates to novel intermediates of the formula STR1 wherein R 1 is hydrogen or lower alkyl and R is STR2--CH 2 OH or--CH 2 X in which X is a conventional leaving group and Y is lower alkyl and the use thereof in a process for the prep

CHEMICAL COMPOUNDS

Compounds of the formula STR1 wherein R 12 is a leaving group, Z is S, O or CH 2 and A is a phenyl, furyl, thienyl or pyridyl ring substituted by a STR2 moiety, in which R 8 and R 9 are various substituents or, when taken together with the nitrogen, may be a specified heterocyclic ring, are intermediates in the preparation of histamine H 2-antagonist anti-ulcer agents of the formula STR3 in which R 1 and R 2 are any of several specified substituents.

1-AMINO-2-[3-(3-PIPERIDINOMETHYLPHENOXY)PROPYLAMINO]CYCLOBUTENE-3,4-DIONE

Certain 1-(substituted amino)-2-(amino or substituted amino) cyclobutene-3,4-diones are potent histamine H 2-antagonists useful in the treatment of peptic ulcers.