861344-74-3

Upstream product

• 16520-62-0 4-Phenyl-1-butyne 
• 861310-42-1 but-3-ynyl-benzene; mercury comp bond 
• 40277-01-8 1-(trimethylsilyl)-4-phenyl-1-butyne 

Downstream Products

• 218902-81-9 (Z)-(4-iodobut-3-en-1-yl)benzene 
• 868701-13-7 octa-3,7-diynyl-benzene 
• 1316239-79-8 (Z)-1-iodo-4-phenylbut-1-en-2-yl diphenyl phosphate 
• 1292358-60-1 1-benzyl-3-hydroxy-3-(4-phenylbut-1-ynyl)indolin-2-one 
• 56693-01-7 (Z)-1,2,3,4,5-pentafluoro-6-(4-phenylbut-1-en-1-yl)benzene 

Relevant academic research and scientific papers

Efficient synthesis of 1-iodoalkynes: Via Al2O3 mediated reaction of terminal alkynes and N -iodosuccinimide

Iodination of terminal alkynes using N-iodosuccinimide (NIS) in the presence of γ-Al2O3 was developed to afford 1-iodoalkynes with good to excellent yields (up to 99%). This described approach featured excellent chemoselectivity, good functional group tolerance, and utilization of an inexpensive catalyst.

Acetic Acid Promoted Direct Iodination of Terminal Alkynes with N -Iodosuccinimide: Efficient Preparation of 1-Iodoalkynes

An efficient and highly chemoselective approach for the direct iodination of terminal alkynes using acetic acid as N -iodosuccinimide activated reagent under metal-free conditions has been developed. This facile process tolerates a variety of terminal alkynes and provides the desired products in good to excellent yields (up to 99percent).

Preparation method of 1-iodoalkyne

The invention discloses a preparation method of 1-iodoalkyne. The method comprises the following step: reacting a terminal alkyne compound with N-iodosuccinimide in a solvent in the presence of aluminum oxide and a molecular sieve to prepare a 1-iodoalkyn

Chloramine Salt Mediated Oxidative Halogenation of Terminal Alkynes with KI or NaBr: Practical Synthesis of 1-Bromoalkynes and 1-Iodoalkynes

A direct oxidative halogenation of terminal alkynes has been realized using chloramine-B as the oxidant and KI or NaBr as the halogen source. This reaction enables a general and practical access to synthetically valuable 1-bromoalkynes and 1-iodoalkynes i

Preparation method of 1-bromoalkyne and 1-iodoalkyne

The invention discloses a preparation method of 1-bromoalkyne and 1-iodoalkyne. The preparation method comprises the following steps that terminal alkyne is adopted as a raw material, a chloramine salt and an iodine salt or a bromine salt is adopted as a

Catalytic electrophilic halogenation of silyl-protected and terminal alkynes: Trapping gold(I) acetylides vs. a Bronsted acid-promoted reaction

In the presence of a cationic gold(I) catalyst and N-halosuccinimide, both trimethylsilyl-protected and terminal alkynes are converted into alkynyl halides. Further experiments showed that silyl-protected alkynes undergo electrophilic iodination and bromination under Bronsted acid catalysis, whilst terminal alkynes require a cationic gold catalyst. The former reactions probably proceed via activation of the electrophile, whilst the latter reactions proceed via a gold(I) acetylide intermediate. Gold-catalysed halogenation was further combined with gold-catalysed hydration and subsequent annulation to provide convenient routes to iodomethyl ketones and five-membered aromatic heterocycles. Copyright

Synthesis and properties of seleno-analog MK-organic dye for photovoltaic cells prepared by CH functionalization reactions of selenophene derivatives

C-H arylation and homocoupling reactions of 2-formylselenophene were carried out with a palladium catalyst. By using these coupling reactions a seleno-analog of MK dye MK-49, which is an organic dye molecule of a dye-sensitized solar cell (DSSC), was synt

Palladium-catalyzed carbene insertion and trapping with carbon nucleophiles

Palladium catalysts are shown to catalyze the three-component coupling of vinyl halides, trimethylsilyldiazomethane. and stabilized carbon nucleophiles. The reaction is believed to proceed through a palladium-carbene intermediate LX(R)Pd=CHSiMe3 that undergoes migration of the vinyl substituent to the electrophilic carbene center to generate an ν3-allylpalladium intermediate. The allylpalladium intermediate is attacked by the carbon nucleophile to generate a vinylsilane product.

Palladium-catalyzed carbene insertion into vinyl halides and trapping with amines

Palladium is shown to catalyze the three-component coupling of vinyl halides, trimethytsilyldiazomethane, and amines to generate allylamines. The mechanism is believed to Involve formation of an R-Pd=CHSiMe3 intermediate that undergoes migratio

Bronsted acid-promoted cyclizations of 1-siloxy-1,5-diynes

We have developed the first HNTf2-promoted 5-endo-dig cyclizations of 1-siloxy-1,5-diynes, which proceed with concomitant formation of C-Hal bonds as a result of halide abstraction from a halocarbon by the intermediate alkenyl cation. This process is enabled by a chemoselective activation of the more electron-rich siloxy alkyne moiety of the diyne cyclization precursor and represents an efficient and highly diastereoselective method for assembly of a range of β-halo enones. Copyright