861389-99-3Relevant academic research and scientific papers
The synthesis of substituted bipiperidine amide compounds as CCR3 ligands: Antagonists versus agonists
Ting, Pauline C.,Umland, Shelby P.,Aslanian, Robert,Cao, Jianhua,Garlisi, Charles G.,Huang, Ying,Jakway, James,Liu, Zhidan,Shah, Himanshu,Tian, Fang,Wan, Yuntao,Shih, Neng-Yang
, p. 3020 - 3023 (2007/10/03)
Structure-activity relationship study of bipiperidine amide 1 has identified the reverse bipiperidine amide 4a as a CC chemokine-3 (CCR3) receptor antagonist. Optimization of the structure-activity relationship of compound 4a has resulted in the identification of a CCR3 antagonist 4i as well as a CCR3 agonist 13.
