861448-90-0

Upstream product

• 808768-94-7 ethyl 2-[3-(2-amino-2-methylpropyl)phenyl]acetate 
• 32634-66-5 Di-p-toluoyl-L-tartaric acid 
• 921598-15-4 ethyl 2-{3-[2-(2-chloroacetamido)-2-methylpropyl]phenyl}acetate 
• 1313220-75-5 C₁₂H₁₇NO₂ 
• 808768-95-8 (3-{2-[(chloroacetyl)amino]-2-methylpropyl}phenyl)acetic acid 
• 808768-96-9 2-[3-(2-hydroxy-2-methylpropyl)phenyl]acetic acid 

Downstream Products

• 921598-21-2 2-[3-(2-amino-2-methylpropyl)phenyl]-N-[(4'-hydroxybiphenyl-3-yl)methyl]acetamide 
• 865589-70-4 [3-(2-tert-butoxycarbonylamino-2-methylpropyl)phenyl]acetic acid 
• 921598-25-6 2-(3-{2-[((2R)-2-{4-benzyloxy-3-[(methylsulfonyl)amino]phenyl}-2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)amino]-2-methylpropyl}phenyl)-N-[(4'-hydroxybiphenyl-3-yl)methyl]-acetamide 
• 921598-22-3 2-[3-(2-{[(2R)-2-{4-(benzyloxy)-3-[(methylsulfonyl)amino]-phenyl}-2-hydroxyethyl]amino}-2-methylpropyl)phenyl]-N-[(4'-hydroxybiphenyl-3-yl)methyl]acetamide 
• 862540-80-5 2-[3-(2-{[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl]amino}-2-methylpropyl)phenyl]-N-[(4'-hydroxybiphenyl-3-yl)methyl]acetamide 
• 861448-93-3 [3-(2-{[(2R)-2-{4-(benzyloxy)-3-[(methylsulfonyl)amino]phenyl}-2-hydroxyethyl]amino}-2-methylpropyl)phenyl]acetic acid 
• 861448-92-2 ethyl (R)-2-(3-{2-[2-hydroxy-2-(4-benzyloxy-3-methanesulfonamidophenyl)ethylamino]-2-methylpropyl}phenyl)acetate 
• 861448-91-1 ethyl (3-{2-[((2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-{4-benzyloxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-2-methylpropyl}phenyl)acetate 
• 921598-16-5 ethyl [3-(2-tert-butoxycarbonylamino-2-methylpropyl)phenyl]acetate 
• 808768-94-7 ethyl 2-[3-(2-amino-2-methylpropyl)phenyl]acetate 

Relevant academic research and scientific papers

Enzymatic desymmetrization route to ethyl [3-(2-amino-2-methylpropyl) phenyl]acetate

An efficient process to ethyl [3-(2-amino-2-methylpropyl)phenyl]acetate 6 has been developed. Key steps include a novel enzymatic desymmetrization of diester 2 and a Ritter reaction between alcohol 4 and chloroacetonitrile, followed by chemoselective deprotection with thiourea.

PROCESS FOR THE PREPARATION OF SULFONAMIDE DERIVATIVES

The invention relates to a process for the preparation of compounds of formula (I) wherein Q1 is a group selected from formulae (II and (III) and a group *-NR6 -Q2-A or, if appropriate, their pharmaceutically acceptable sa

Sulfonamide derivatives for the treatment of diseases

The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.