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Tyr(Me)1-dermorphin is a synthetic peptide derived from the naturally occurring opioid peptide dermorphin, which is extracted from the skin secretions of the Phyllomedusa sauvagei frog. This modified version of dermorphin features a methylated tyrosine residue at the first position, enhancing its stability and potency. It is known for its high affinity and selectivity for the μ-opioid receptor, making it a potent analgesic with potential therapeutic applications in pain management. However, due to its strong binding to the receptor, it also carries a risk of addiction and side effects, which limits its clinical use. Research on Tyr(Me)1-dermorphin and its analogs continues to explore ways to harness its pain-relieving properties while mitigating the adverse effects associated with opioid use.

86146-54-5

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86146-54-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 86146-54-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,6,1,4 and 6 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 86146-54:
(7*8)+(6*6)+(5*1)+(4*4)+(3*6)+(2*5)+(1*4)=145
145 % 10 = 5
So 86146-54-5 is a valid CAS Registry Number.

86146-54-5Downstream Products

86146-54-5Relevant academic research and scientific papers

Structure-Activity Studies of Dermorphin. Synthesis and Some Pharmacological Data of Dermorphin and Its 1-Substiituted Analogues

Darlak, Krzysztof,Grzonka, Zbigniew,Janicki, Piotr,Czlonkowski, Andrzej,Gumulka, S. Witold

, p. 1445 - 1447 (1983)

Dermorphin and its analogues substituted at position 1 by N-acetyltyrosine, O-methyltyrosine, phenylalanine, D-phenylalanine, or alanine were obtained by solid-phase peptide synthesis.Their pharmacological effects were studied in vitro by the guinea pig ileum method and in vivo by the hot plate method, and the results were compared with those of morphine.The most pronounced activity was shown for dermorphin.A radioreceptor study showed a moderate affinity of dermorphin and its Tyr(Me)1 analogue for the opiate receptor sites from striatal homogenates.

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