86156-93-6

Basic information

• Product Name: 3-FLUORO-4-NITROBENZENESULFONYL CHLORIDE
• Synonyms: 3-FLUORO-4-NITROBENZENESULFONYL CHLORIDE;Benzenesulfonyl chloride, 3-fluoro-4-nitro- (9CI);3-Fluoro-4-nitrobenzenesulfony;3-Fluro-4-nitro-benzensulfonyl chloride;3-fluoro-4-nitrobenzene-1-sulfonyl chloride;3-fluoro-4-nitrophenylsulfonyl chloride
• CAS NO: 86156-93-6
• Molecular Formula: C₆H₃ClFNO₄S
• Molecular Weight: 239.61
• Product Categories: SULFONYLHALIDE;Fluorine series
• Mol File: 86156-93-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 45-48°C
• Boiling Point: 126°C/0.25mm
• Flash Point: 167.2°C
• Appearance: /
• Density: 1.685g/cm³
• Vapor Pressure: 7.62E-05mmHg at 25°C
• Refractive Index: 1.568
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive: Moisture Sensitive
• CAS DataBase Reference: 3-FLUORO-4-NITROBENZENESULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-FLUORO-4-NITROBENZENESULFONYL CHLORIDE(86156-93-6)
• EPA Substance Registry System: 3-FLUORO-4-NITROBENZENESULFONYL CHLORIDE(86156-93-6)

Safety Data

• Hazard Codes: Xi,C
• Statements: 34
• Safety Statements: 26-36/37/39-45
• RIDADR: 3261
• HazardClass: IRRITANT, CORROSIVE
• Hazardous Substances Data: 86156-93-6(Hazardous Substances Data)

Usage

General Description

3-Fluoro-4-nitrobenzenesulfonyl chloride is a chemical compound with the molecular formula C6H3ClFNO4S. It is a sulfonating agent and a key intermediate in the synthesis of pharmaceuticals and agrochemicals. 3-FLUORO-4-NITROBENZENESULFONYL CHLORIDE is used in the production of various drugs and pesticides due to its ability to react with amines, alcohols, and phenols to form sulfonamides, sulfonates, and sulfonamides, making it an important building block in organic synthesis. Additionally, it is also used as a reagent in the synthesis of dyes and pigments. It is considered a hazardous material and should be handled and stored with caution due to its toxic and corrosive properties.

InChI:InChI=1/C6H3ClFNO4S/c7-14(12,13)4-1-2-6(9(10)11)5(8)3-4/h1-3H

Upstream product

• 2369-13-3 3-fluoro-4-nitroaniline 

Downstream Products

• 937397-44-9 {1-benzyl-3-[(3-fluoro-4-nitro-benzenesulfonyl)-isobutyl-amino]-2-hydroxy-propyl}-carbamic acid hexahydro-furo[2,3-b]furan-3-yl ester 
• 121-57-3 4-aminobenzene sulfonic acid 
• 2369-25-7 4-amino-3-fluorobenzenesulfonic acid 
• 1450924-20-5 3-hydroxy-4-((2-methoxy-4-(trifluoromethyl)phenyl)amino)-N-(4-methoxybenzyl)-N-(thiazol-2-yl)benzenesulfonamide 
• 1450922-65-2 4-(2-methoxy-4-(trifluoromethyl)phenyl)-3-oxo-N-(thiazol-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide 
• 1450923-58-6 3-fluoro-N-(4-methoxybenzyl)-4-nitro-N-(thiazol-2-yl)benzenesulfonamide 
• 1450919-85-3 3-phenyl-N-(1,2,4-thiadiazol-5-yl)-4-(4-(trifluoromethyl)phenyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide 
• 1450919-81-9 4-phenyl-N-(1,2,4-thiadiazol-5-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide 

Relevant articles and documents

3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

BROADSPECTRUM SUBSTITUTED BENZIMIDAZOLE SULFONAMIDE HIV PROTEASE INHIBITORS

The present invention concerns the compounds having the formula (I), wherein N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites thereof, wherein R1 and R8 each are H, optionally substituted C1-6alkyl, C2-6alkenyl, C3-7cycloalkyl, aryl, Het1, Het2; R1 may also be a radical of formula (R11aR11b)NC(R10aRl0b)CR9-; t is 0, 1 or 2; R2 is H or C1-6alkyl; L is -C(=O)-, -O-C(=O)-, -NR8-C(=O)-, -O-C1-6alkanediyl-C(=O)-, -NR8-C1-6alkanediyl-C(=O)-, -S(=O)2-, -O-S(=O)2-, -NR8-S(=O)2 ; R3 is C1-6alkyl, aryl, C3-7cycloalkyl, C3-7cycloalkylC1-4alkyl, or arylC1-4alkyl; R4 is H, C1-4alkylOC(=O), carboxyl, aminoC(=O), mono- or di(C1-4alkyl)aminoC(=O), C3-7cycloalkyl, C2-6alkenyl, C2-6alkynyl or optionally substituted C1-6alkyl; A is C1-6alkanediyl, -C(=O)-, -C(=S)-, -S(=O)2-, C1-6alkanediyl-C(=O)-, C1-6 alkanediyl-C(=S)- or C1-6alkanediyl-S(=O)2-; R5 is H, OH, C1-6alkyl, Het1C1-6alkyl, Het2C1-6 alkyl, optionally substituted amino--C1-6alkyl; R6 is C1-6alkylO, Het1, Het1O, Het2, Het2O, aryl, arylO, C1-6 alkyloxy-carbonylamino or amino; and in case _A- is other than C1-6alkanediyl then R6 may also be C1-6alkyl, Het1C1-4alkyl, Het1OC1-4alkyl, Het2C1-4alkyl, Het2OC1-4alkyl, arylC1-4alkyl, arylOC1-4alkyl or aminoC1-4alkyl; whereby each of the amino groups in the definition of R6 may optionally be substituted; R5 and _A-R6 taken together with the nitrogen atom to which they are attached may also form Het1 or Het2, R12 , is H, - NH2, _NR5AR6, - C1-6alkyl or alkyl-W-R14 , wherein said alkyl is optionally substituted with halogen, hydroxy, aryl, heteroaryl, Het1, Het2, or amino wherein said amino is optionally mono- or di-substituted with C1-4alkyl and R13 is H, C1-6-alkyl, optionally substituted by aryl, Het1, Het2, hydroxy, halogen, amino whereby the amino group may be optionally be mono- or di-substituted with C1-4alkyl.