86161-49-1

Basic information

• Product Name: Z-ILE-NH2
• Synonyms: N-ALPHA-CARBOBENZOXY-L-ISOLEUCINE ALPHA-AMIDE;Z-ISOLEUCINE-NH2;Z-L-ISOLEUCINE AMIDE;Z-ILE-NH2;CarbaMic acid, [(1S,2S)-1-(aMinocarbonyl)-2-Methylbutyl]-, phenylMethyl ester;L-Z-IsoleucinaMide;Z-(2S,3S)-2-amino-3-methylpentanoic acid amide;Z-(2S,3S)-2-amino-3-methylvaleric acid amide
• CAS NO: 86161-49-1
• Molecular Formula: C₁₄H₂₀N₂O₃
• Molecular Weight: 264.32
• Mol File: 86161-49-1.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: Store at RT.
• CAS DataBase Reference: Z-ILE-NH2(CAS DataBase Reference)
• NIST Chemistry Reference: Z-ILE-NH2(86161-49-1)
• EPA Substance Registry System: Z-ILE-NH2(86161-49-1)

Safety Data

• Hazardous Substances Data: 86161-49-1(Hazardous Substances Data)

Usage

Description

Z-ILE-NH2 is a synthetic dipeptide compound that belongs to the class of amino acids. It is composed of two amino acid units, isoleucine (ILE) and a C-terminal carboxamide group (–NH2), joined together by a peptide bond. The chemical name is derived from its structure, which includes a Z-type, or cis, conformation. Z-ILE-NH2 has potential applications in pharmaceutical research and drug development, as well as in studying peptide chemistry and biochemistry due to its unique structure and conformational properties.

Uses

Used in Pharmaceutical Research and Drug Development:
Z-ILE-NH2 is used as a building block for more complex peptide-based molecules, contributing to the development of new drugs and therapies.
Used in Peptide Chemistry and Biochemistry:
Z-ILE-NH2 is used as an important reference compound for studying peptide chemistry and biochemistry, providing insights into the structure, properties, and behavior of peptides.

Upstream product

• 3160-59-6 N-Cbz-L-Isoleucine 
• 3282-30-2 pivaloyl chloride 
• 3391-99-9 N-Z-L-isoleucine N-hydroxysuccinimide ester 

Downstream Products

• 17330-33-5 (R)-2-((1S,2S)-1-benzyloxycarbonylamino-2-methyl-butyl)-4,5-dihydro-thiazole-4-carboxylic acid ethyl ester 
• 17343-62-3 L-erythro-2-benzyloxycarbonylamino-3-methyl-pentanimidic acid ethyl ester 
• 17021-53-3 (S,S)-N-Benzyloxycarbonyl-2-(1-amino-2-methylbutyl)-thiazol-4-carbonsaeureethylester 
• 17021-52-2 (S,S)-N-Benzyloxycarbonyl-isoleucinthioamid 
• 82985-39-5 Z-Leu-Ile-NH₂ 
• 92398-97-5 Z-Ser-Leu-Ile-NH₂ 
• 125453-39-6 [1-(1-Amino-2-methyl-propylcarbamoyl)-2-methyl-butyl]-carbamic acid benzyl ester 
• 125453-22-7 [1-(1-Benzotriazol-1-yl-2-methyl-propylcarbamoyl)-2-methyl-butyl]-carbamic acid benzyl ester 

Relevant articles and documents

Irreversible HIV protease inhibitors, intermediates, compositions and processes for the preparation thereof

The present invention provides cis-epoxide compounds represented by formula (I-1), (I-2) or (I-3) which are useful for treating or preventing diseases caused by HIV infection: STR1 wherein: A, B, D, E, R1, R10, R11, K, G, Q, r and J have the meanings as defined in the specification.

Synthesis of PHI (Peptide Histidine Isoleucine) and Related Peptides and Immunochemical Confirmation of Amino Acid Residue in Position 24 of PHI with use of the Synthetic Peptides

An immunochemical approach, using synthetic peptides, was employed to establish the nature of residue 24 in the amino acid sequence of PHI (peptide histidine isoleucine).PHI(20-27) and 24>-PHI(20-27) were synthesized by conventional solutio