86161-49-1

Usage

Uses

Used in Pharmaceutical Research and Drug Development:
Z-ILE-NH2 is used as a building block for more complex peptide-based molecules, contributing to the development of new drugs and therapies.
Used in Peptide Chemistry and Biochemistry:
Z-ILE-NH2 is used as an important reference compound for studying peptide chemistry and biochemistry, providing insights into the structure, properties, and behavior of peptides.

Upstream product

• 3160-59-6 N-Cbz-L-Isoleucine 
• 3282-30-2 pivaloyl chloride 
• 3391-99-9 N-Z-L-isoleucine N-hydroxysuccinimide ester 

Downstream Products

• 17343-62-3 L-erythro-2-benzyloxycarbonylamino-3-methyl-pentanimidic acid ethyl ester 
• 17330-33-5 (R)-2-((1S,2S)-1-benzyloxycarbonylamino-2-methyl-butyl)-4,5-dihydro-thiazole-4-carboxylic acid ethyl ester 
• 17021-53-3 (S,S)-N-Benzyloxycarbonyl-2-(1-amino-2-methylbutyl)-thiazol-4-carbonsaeureethylester 
• 17021-52-2 (S,S)-N-Benzyloxycarbonyl-isoleucinthioamid 
• 82985-39-5 Z-Leu-Ile-NH₂ 
• 92398-97-5 Z-Ser-Leu-Ile-NH₂ 
• 125453-39-6 [1-(1-Amino-2-methyl-propylcarbamoyl)-2-methyl-butyl]-carbamic acid benzyl ester 
• 125453-22-7 [1-(1-Benzotriazol-1-yl-2-methyl-propylcarbamoyl)-2-methyl-butyl]-carbamic acid benzyl ester 

Relevant academic research and scientific papers

Irreversible HIV protease inhibitors, intermediates, compositions and processes for the preparation thereof

The present invention provides cis-epoxide compounds represented by formula (I-1), (I-2) or (I-3) which are useful for treating or preventing diseases caused by HIV infection: STR1 wherein: A, B, D, E, R1, R10, R11, K, G, Q, r and J have the meanings as defined in the specification.

Cis-epoxide derivatives useful as irreversible HIV protease inhibitors and process and intermediates for their preparation

The present invention provides cis-epoxide compounds represented by formula (I-1), (I-2) or (I-3) which are useful for treating or preventing diseases caused by HIV infection: wherein:, A, B, D, E, R1, R10, R11, K, G, Q, r and J have the meanings as defined in the specification.

Synthesis of PHI (Peptide Histidine Isoleucine) and Related Peptides and Immunochemical Confirmation of Amino Acid Residue in Position 24 of PHI with use of the Synthetic Peptides

An immunochemical approach, using synthetic peptides, was employed to establish the nature of residue 24 in the amino acid sequence of PHI (peptide histidine isoleucine).PHI(20-27) and 24>-PHI(20-27) were synthesized by conventional solutio

Dichlorotris(dimethylamino)phosphorane as a Dehydratisation Reagent for the Preparation of N-Protected Amino Acid Amides

Besides for the synthesis of peptides and activated esters dichlorotris(dimethylamino)phosphorane (2) now proved to be an excellent reagent for the preparation of N-protected amino acid amides.