861650-18-2Relevant academic research and scientific papers
Aromatic annulation on the p-menthane monoterpenes: Enantiospecific synthesis of the trans and cis isomers of calamenene and 8-hydroxycalamenene
Serra, Stefano,Fuganti, Claudio
, p. 4769 - 4772 (2005)
A new enantiospecific route to sesquiterpenes of the calamenene family is described. The synthetic pathway starts from easily available 3-oxygenated-p-menthane monoterpenes and affords the title compounds by a homologation-benzannulation sequence. The trans and cis isomers of the natural compounds calamenene and 8-hydroxycalamenene were obtained in enantiopure form starting from (-)-menthone and (+)-isomenthone, respectively.
