86177-59-5

Upstream product

• 127099-85-8 N-Cyanoguanidine 
• 139-59-3 4-phenoxyanilin 

Downstream Products

• 86177-36-8 N-[4-(4-Benzyloxy-3-diethylaminomethyl-phenylamino)-6-trifluoromethyl-pyrimidin-2-yl]-N'-(4-phenoxy-phenyl)-guanidine 
• 86177-33-5 N-{4-[4-Hydroxy-3-(4-methyl-piperazin-1-ylmethyl)-phenylamino]-6-trifluoromethyl-pyrimidin-2-yl}-N'-(4-phenoxy-phenyl)-guanidine 
• 86177-35-7 N-[4-(3-Diethylaminomethyl-4-methoxy-phenylamino)-6-trifluoromethyl-pyrimidin-2-yl]-N'-(4-phenoxy-phenyl)-guanidine 
• 86177-32-4 N-[4-(3-Diethylaminomethyl-4-hydroxy-phenylamino)-6-trifluoromethyl-pyrimidin-2-yl]-N'-(4-phenoxy-phenyl)-guanidine 
• 86177-34-6 N-[4-(3-Ethylaminomethyl-4-methoxy-phenylamino)-6-trifluoromethyl-pyrimidin-2-yl]-N'-(4-phenoxy-phenyl)-guanidine 
• 86177-31-3 N-[4-(3-Dimethylaminomethyl-4-hydroxy-phenylamino)-6-trifluoromethyl-pyrimidin-2-yl]-N'-(4-phenoxy-phenyl)-guanidine 

Relevant academic research and scientific papers

Incorporation of a Biguanide Scaffold Enhances Drug Uptake by Organic Cation Transporters 1 and 2

Membrane transporters play a significant role in the transport of many endogenous and exogenous compounds. The knowledge of transporter substrate requirements has allowed further development of drugs that utilize them to ensure tissue permeation. In this

Synthesis and antifilarial activity of N-[4-[[4-alkoxy-3-[(dialkylamino)methyl]phenyl]amino]-2-pyrimidinyl]-N'-ph enylguanidines

A series of N-[4-[[4-alkoxy-3-[(dialkylamino)methyl]phenyl]amino]-2-pyrimidinyl]-N' -phenylguanidines have been synthesized for antifilarial evaluation. Reaction of the appropriate benzenamines with N-cyanoguanidine, followed by condensation of the result