861806-27-1Relevant academic research and scientific papers
Synthesis of some diguanidino 1-methyl-2,5-diaryl-1H-pyrroles as antifungal agents
Jana, Gour Hari,Jain, Sanjay,Arora, Sudershan K.,Sinha, Neelima
, p. 3592 - 3595 (2007/10/03)
A series of novel 2,5-bis(guanidino-aryl)-1-methyl-1H-pyrroles 9a-h has been synthesized starting from 1-methyl-1H-pyrrole. The antifungal activities of compounds were evaluated by in vitro agar diffusion and broth dilution assay against Candida spp. and Aspergillus spp. Compound 9c from this series was found to be equipotent or more potent than fluconazole, whereas compound 9d was comparable to fluconazole against most of the tested strains.
Synthesis of dicationic 2,5-diarylpyrroles
Arafa, Reem K.,Brun, Reto,Werbovetz, Karl A.,Tanious, Farial A.,David Wilson,Boykin, David W.
, p. 423 - 428 (2007/10/03)
A new series of dicationic reversed amidine derivatives 4a-f and a substituted guanidine analog 7 of 2,5-diarylpyrrole obtained starting from the corresponding 2,5-bis(aminoaryl)pyrroles 3a-c are reported. The results of DNA binding studies and antimicrob
