861852-12-2Relevant academic research and scientific papers
Synthesis of dioxane-based antiviral agents and evaluation of their biological activities as inhibitors of Sindbis virus replication
Kim, Ha Young,Kuhn, Richard J.,Patkar, Chinmay,Warrier, Ranjit,Cushman, Mark
, p. 2667 - 2679 (2007)
The crystal structure of the Sindbis virus capsid protein contains one or two solvent-derived dioxane molecules in the hydrophobic binding pocket. A bis-dioxane antiviral agent was designed by linking the two dioxane molecules with a three-carbon chain ha
Design, synthesis, and evaluation of dioxane-based antiviral agents targeted against the Sindbis virus capsid protein
Kim, Ha Young,Patkar, Chinmay,Warrier, Ranjit,Kuhn, Richard,Cushman, Mark
, p. 3207 - 3211 (2007/10/03)
Dioxane-based antiviral agents targeted to the hydrophobic binding pocket of Sindbis virus capsid protein were designed by computer graphics molecular modeling and synthesized. Virus production using SIN-IRES-Luc and capsid assembly were monitored to eval
