406913-88-0

Usage

Uses

Used in Chemical Synthesis:
(2R)-1,4-Dioxane-2-methanol is used as a solvent in chemical synthesis for its ability to dissolve a wide range of substances, facilitating various chemical reactions.
Used in Pharmaceutical Production:
In the pharmaceutical industry, (2R)-1,4-Dioxane-2-methanol is used as a solvent or reagent in the synthesis of certain drugs, contributing to the development of new medicinal compounds.
Used in Dye and Pesticide Manufacturing:
(2R)-1,4-Dioxane-2-methanol is utilized in the production of dyes and pesticides, where it serves as a key component in the manufacturing process, enhancing the effectiveness and quality of the final products.
However, it is important to note that (2R)-1,4-Dioxane-2-methanol is considered a hazardous chemical. Exposure to high levels can result in irritation to the skin, eyes, and respiratory system, and it may have detrimental effects on aquatic organisms and the environment. Therefore, strict safety measures and precautions should be implemented during its handling and use to mitigate potential risks.

Upstream product

• 406913-84-6 2-hydroxymethyl-1,4-dioxane hydrogen phthalate 
• 18371-74-9 1-chloro-3-(2-hydroxyethoxy)-2-propanol 
• 29908-11-0 (+/-)-2-(hydroxymethyl)-1,4-dioxane 
• 861852-08-6 (2R)-2-[(2-chloroethoxy)methyl]oxirane 
• 406913-91-5 Phthalic acid mono-(S)-1-[1,4]dioxan-2-ylmethyl ester 
• 861852-07-5 (S)-1-(2-chloroethoxy)-3-chloropropan-2-ol 
• 406913-87-9 (1S,5R)-3,6,8-trioxabicyclo[3.2.1]octane 

Downstream Products

• 917882-64-5 ((2S)-1,4-dioxan-2-yl)methyl 4-methylbenzenesulfonate 
• 917882-66-7 MK-2461 
• 1233483-72-1 benzyl {[[(2R)-1,4-dioxan-2-ylmethyl](methyl)amino]sulfonyl}carbamate 
• 861852-12-2 (R)-2-[(2-phenethyl-1,3-dithian-2-yl)methyl]-1,4-dioxane 

Relevant academic research and scientific papers

Meso-Tetra(dioxanyl)porphyrins: Neutral, low molecular weight, and chiral porphyrins with solubility in aqueous solutions

The synthesis of the low-molecular weight, meso-Tetra(dioxan-2-yl)porphyrin with considerable solubility in aqueous solution is described. The key intermediate dioxan-2-carbaldehyde is accessible in either racemic or in stereo-pure forms from commercially available starting materials in three steps. Using 4 × 1 or 2 + 2-Type syntheses provide the porphyrin in modest yields. While the racemic aldehyde created an intractable mixture of diastereomers, the enantiopure aldehyde created a single enantiomer of the target porphyrin. The porphyrin was spectroscopically characterized. As its free base or zinc complex, it showed excellent solubility properties in organic and aqueous solvents, though free water-solubility was not achieved. The work expands on the availability of chiral porphyrins and neutral porphyrins with considerable solubility in aqueous solution.

1,3-THIAZOL-2-YL SUBSTITUTED BENZAMIDES

The present invention relates to 1,3-thiazol-2-yl substituted benzamide compounds of general formula (I) as described and defined herein, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neurogenic disorder, as a sole agent or in combination with other active ingredients.

Process development and large-scale synthesis of a c-Met kinase inhibitor

A highly convergent synthesis of c-Met kinase inhibitor 1 has been demonstrated on a multikilogram scale using three key fragments: dihalotricyclic core 2, chiral sulfamide side chain 3, and pyrazole boronic ester 4. The chirality in sulfamide side chain 3 was installed using the cheap and readily available starting material (S)-epichlorohydrin. A total of 2.71 kg of 1 were isolated in seven steps (the longest linear sequence).

Synthesis of dioxane-based antiviral agents and evaluation of their biological activities as inhibitors of Sindbis virus replication

The crystal structure of the Sindbis virus capsid protein contains one or two solvent-derived dioxane molecules in the hydrophobic binding pocket. A bis-dioxane antiviral agent was designed by linking the two dioxane molecules with a three-carbon chain ha

Design, synthesis, and evaluation of dioxane-based antiviral agents targeted against the Sindbis virus capsid protein

Dioxane-based antiviral agents targeted to the hydrophobic binding pocket of Sindbis virus capsid protein were designed by computer graphics molecular modeling and synthesized. Virus production using SIN-IRES-Luc and capsid assembly were monitored to eval

2-Hydroxymethyl-1,4-dioxane: Synthesis, resolution and determination of the absolute configurations of the enantiomers

2-Hydroxymethyl-1, 4-dioxane 3 was resolved via salt formation between its hydrogen phthalate and (R)- or (S)-1-phenylethylamine, selective crystallization of the resultant diastereomeric mixtures and subsequent recovery of its enantiomers by saponification. The progress of the resolution was followed by chiral HPLC and the absolute stereochemistry of the two enantiomers determined by comparison of their specific rotations with that of (R)-3 synthesized from enantiomerically pure (R)-1-O-benzylglycerol. The results of the synthesis of 3 and of its resolution are discussed and compared with those previously obtained for 1,2-isopropylidene glycerol evaluating the consequences of replacement of ispropylidene with an ethylene bridge.