406913-88-0

Basic information

• Product Name: (2R)-1,4-Dioxane-2-methanol
• Synonyms: (2R)-1,4-Dioxane-2-methanol;1,4-Dioxane-2-methanol, (2R)-;(R)-(1,4-Dioxan-2-yl)Methanol;(2R)-1,4-DIOXAN-2-YLMETHANOL
• CAS NO: 406913-88-0
• Molecular Formula: C₅H₁₀O₃
• Molecular Weight: 118.13
• Mol File: 406913-88-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 208.2±15.0 °C(Predicted)
• Appearance: /
• Density: 1.102
• Storage Temp.: 2-8°C
• PKA: 14.24±0.10(Predicted)
• CAS DataBase Reference: (2R)-1,4-Dioxane-2-methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (2R)-1,4-Dioxane-2-methanol(406913-88-0)
• EPA Substance Registry System: (2R)-1,4-Dioxane-2-methanol(406913-88-0)

Safety Data

• Hazardous Substances Data: 406913-88-0(Hazardous Substances Data)

Usage

General Description

(2R)-1,4-Dioxane-2-methanol is a chemical compound with the molecular formula C4H10O3. It is also known as dioxolane and is a colorless liquid with a mild, sweet odor. (2R)-1,4-Dioxane-2-methanol is commonly used as a solvent in various industrial and laboratory applications, including as a reagent in organic synthesis. It is also used in the production of pharmaceuticals, dyes, and pesticides. However, (2R)-1,4-Dioxane-2-methanol is considered to be a hazardous chemical and exposure to high levels of this compound can cause irritation to the skin, eyes, and respiratory system. It may also have harmful effects on aquatic organisms and the environment. Therefore, proper safety precautions should be taken when handling and using this chemical.

Upstream product

• 406913-87-9 (1S,5R)-3,6,8-trioxabicyclo[3.2.1]octane 
• 406913-91-5 Phthalic acid mono-(S)-1-[1,4]dioxan-2-ylmethyl ester 
• 861852-08-6 (2R)-2-[(2-chloroethoxy)methyl]oxirane 
• 861852-07-5 (S)-1-(2-chloroethoxy)-3-chloropropan-2-ol 
• 29908-11-0 (+/-)-2-(hydroxymethyl)-1,4-dioxane 
• 18371-74-9 1-chloro-3-(2-hydroxyethoxy)-2-propanol 
• 406913-84-6 2-hydroxymethyl-1,4-dioxane hydrogen phthalate 

Downstream Products

• 1233483-72-1 benzyl {[[(2R)-1,4-dioxan-2-ylmethyl](methyl)amino]sulfonyl}carbamate 
• 917882-66-7 MK-2461 
• 917882-64-5 ((2S)-1,4-dioxan-2-yl)methyl 4-methylbenzenesulfonate 
• 861852-12-2 (R)-2-[(2-phenethyl-1,3-dithian-2-yl)methyl]-1,4-dioxane 

Relevant articles and documents

Meso-Tetra(dioxanyl)porphyrins: Neutral, low molecular weight, and chiral porphyrins with solubility in aqueous solutions

The synthesis of the low-molecular weight, meso-Tetra(dioxan-2-yl)porphyrin with considerable solubility in aqueous solution is described. The key intermediate dioxan-2-carbaldehyde is accessible in either racemic or in stereo-pure forms from commercially available starting materials in three steps. Using 4 × 1 or 2 + 2-Type syntheses provide the porphyrin in modest yields. While the racemic aldehyde created an intractable mixture of diastereomers, the enantiopure aldehyde created a single enantiomer of the target porphyrin. The porphyrin was spectroscopically characterized. As its free base or zinc complex, it showed excellent solubility properties in organic and aqueous solvents, though free water-solubility was not achieved. The work expands on the availability of chiral porphyrins and neutral porphyrins with considerable solubility in aqueous solution.

Process development and large-scale synthesis of a c-Met kinase inhibitor

A highly convergent synthesis of c-Met kinase inhibitor 1 has been demonstrated on a multikilogram scale using three key fragments: dihalotricyclic core 2, chiral sulfamide side chain 3, and pyrazole boronic ester 4. The chirality in sulfamide side chain 3 was installed using the cheap and readily available starting material (S)-epichlorohydrin. A total of 2.71 kg of 1 were isolated in seven steps (the longest linear sequence).

Design, synthesis, and evaluation of dioxane-based antiviral agents targeted against the Sindbis virus capsid protein

Dioxane-based antiviral agents targeted to the hydrophobic binding pocket of Sindbis virus capsid protein were designed by computer graphics molecular modeling and synthesized. Virus production using SIN-IRES-Luc and capsid assembly were monitored to eval