861882-83-9Relevant academic research and scientific papers
Structure-based design and synthesis of pyrazinones containing novel P 1 'side pocket' moieties as inhibitors of TF/VIIa
Schweitzer, Barbara A.,Neumann, William L.,Rahman, Hayat K.,Kusturin, Carrie L.,Sample, Kirby R.,Poda, Gennadiy I.,Kurumbail, Ravi G.,Stevens, Anna M.,Stegeman, Roderick A.,Stallings, William C.,South, Michael S.
, p. 3006 - 3011 (2007/10/03)
We describe the structure-based design, synthesis, and enzymatic activity of a series of substituted pyrazinones as inhibitors of the TF/VIIa complex. These inhibitors contain substituents meta to the P1 amidine designed to explore additional i
