861896-81-3

Upstream product

• 17812-07-6 Benzoylacrylic acid 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 98-86-2 acetophenone 
• 298-12-4 Glyoxilic acid 

Downstream Products

• 861896-84-6 (2R,4S)-4-hydroxy-4-phenyl-2-{[(1R)-1-phenylethyl]amino}butanoic acid 
• 583-06-2 3-benzoylacrylic acid 
• 1273328-86-1 (1R,3R)-3-((R)-1-phenylethylamino)-1-phenylbutane-1,4-diol 
• 1273328-94-1 (1S,3R)-3-((R)-1-phenylethylamino)-1-phenylbutane-1,4-diol 
• 1273328-66-7 C₁₈H₂₁NO₃ 
• 384835-42-1 (1R,3R)-N-(3-hydroxy-1-hydroxymethyl-3-phenylprop-1-yl)dodecanamide 
• 383418-30-2 (1R,3S)-dodecanoic acid (3-hydroxy-1-hydroxymethyl-3-phenylpropyl)amide 

Relevant academic research and scientific papers

The first example of a crystallization-induced asymmetric transformation (CIAT) in the Mannich reaction

The novel synthesis of highly enantioenriched N-substituted α-amino-γ-alkyl(aryl)-γ-oxobutanoic acids is described. The process involves the combination of a crystallization-induced asymmetric transformation (CIAT) and the Mannich reaction. The role of retro-Mannich and retro-Michael reactions in the mechanism of the highly stereoselective transformation is also discussed.

Crystallization-induced asymmetric transformations (CIAT): Stereoconvergent acid-catalyzed lactonization of substituted 2-amino-4-aryl-4-hydroxybutanoic acids

Acid-catalyzed lactonization in dilute hydrochloric acid of N-substituted 2-amino-4-aryl-4-hydroxybutanoic acids with electron donating aryl substituents is stereoconvergent. The stereochemical outcome is controlled by the precipitation of little soluble