861927-65-3Relevant academic research and scientific papers
An investigation of structure-reactivity relationships of δ-alkenyl oximes; Competitive thermal reactions leading to cyclic nitrones and/or N-unsubstituted bicyclic isoxazolidines
Doyle, Linda,Heaney, Frances
experimental part, p. 7041 - 7049 (2010/10/18)
Thermal reactions of C-aryl δ-alkenyl oximes give N-unsubstituted bicylic lactone, lactam and pyrrolidine fused isoxazolidines by an intramolecular oxime olefin cycloaddition pathway (IOOC) and/or cyclic nitrones by an azaprotio cyclotransfer (APT) route; a number of factors, including the nature of the aryl group, the oxime geometry and the structure of the linker between the oxime and the terminal alkene, contribute to the competition. The nature of the aryl group, oxime geometry, and the structure of the linker between the oxime and the alkene influence the reactivity of C-aryl δ-alkenyl oximes.
