3112-46-7

Usage

Uses

Used in Pharmaceutical and Agrochemical Synthesis:
Mesitylglyoxylic acid is used as a key building block for the synthesis of various pharmaceuticals and agrochemicals, due to its ability to be incorporated into complex molecular structures, enhancing the development of new drugs and pesticides.
Used in Chemistry as a Chelating Agent:
In the field of chemistry, mesitylglyoxylic acid is utilized as a chelating agent for metal ion recognition and extraction, capitalizing on its capacity to form stable complexes with metal ions, which is crucial for various analytical and industrial processes.
Used in Antimicrobial and Antiviral Applications:
Mesitylglyoxylic acid is employed for its antimicrobial and antiviral properties, serving as a potential agent in the development of treatments and preventive measures against infectious diseases caused by bacteria and viruses.
Used in Materials Science for Polymer Synthesis:
In materials science, mesitylglyoxylic acid is used as a building block for polymer materials, contributing to the advancement of new polymeric materials with specific properties for various applications, such as coatings, adhesives, or composites.

InChI:InChI=1/C11H12O3/c1-6-4-7(2)9(8(3)5-6)10(12)11(13)14/h4-5H,1-3H3,(H,13,14)

Upstream product

• 1667-01-2 2,4,6-Trimethylacetophenone 
• 37167-44-5 4-[(2,4,6-trimethyl-phenyl)-oxo-thioacetyl]-morpholine 
• 5524-57-2 ethyl 2-(2,4,6-trimethylphenyl)-2-oxoacetate 
• 19909-65-0 dimesityl-butanetetraone 
• 576-83-0 2,4,6-trimethylphenyl bromide 
• 6488-59-1 diphenylparabanic acid 
• 1352131-41-9 5-hydroxy-5-(2,4,6-trimethylphenyl)-N,N'-diphenylimidazolidine-2,4-dione 
• 2633-66-1 2-mesitylmagnesium bromide 
• 108-67-8 1,3,5-trimethyl-benzene 
• 873377-42-5 2-hydroxy-1.1-diphenyl-3-(2.4.6-trimethyl-phenyl)-propen-⁽¹⁾-one-⁽³⁾ 
• 854658-26-7 5-bromo-6-mesityl-6-oxo-hexanoic acid 
• 553-90-2 Dimethyl oxalate 

Downstream Products

• 487-68-3 mesytaldehyde 
• 480-63-7 mesitylenecarboxylic acid 
• 2571-52-0 cyanomesitylene 
• 20797-56-2 2,4,6-trimethylmandelic acid 
• 4408-60-0 2-mesitylacetic acid 
• 861516-92-9 (4-carboxy-2,6-dimethyl-phenyl)-glyoxylic acid 
• 33629-91-3 N-phenyl-1-(2,4,6-trimethylphenyl)methanimine 
• 124-38-9 carbon dioxide 
• 1236046-52-8 mesityl(2-(pyridin-2-yl)phenyl)methanone 
• 861927-65-3 allyl 2-mesityl-2-oxoacetate 
• 954-16-5 2,4,6-Trimethylbenzophenon 
• 2346-67-0 2-(2,4,6-trimethylbenzoyl)-benzoic acid 
• 1533429-32-1 2-mesityl-3-[(trimethylsilyl)ethynyl]quinoxaline 
• 1613740-06-9 (S)-mesityl-2-(methyl(phenyl)amino)-2-oxoethyl 3-phenylpropanoate 

Relevant academic research and scientific papers

Selective photoredox decarboxylation of α-ketoacids to allylic ketones and 1,4-dicarbonyl compounds dependent on cobaloxime catalysis

A photoredox/cobaloxime co-catalyzed coupling reaction of α-ketoacids and methacrylates to obtain allylic ketones is described. Without the cobaloxime catalyst, 1,4-dicarbonyl compounds are generated. The cobaloxime catalyst enables dehydrogenation to generate the formation of new olefins. The generality, good substrate scope and mild conditions are good features in the photoredox/cobaloxime catalysis protocol, and this method will provide new opportunities for the functionalization of more olefins.

Copper-catalyzed oxidative decarboxylative coupling of α-keto acids and sulfoximines

A copper-catalyzed oxidative decarboxylative coupling of α-keto acids with NH-sulfoximines has been developed. With CuBr as the catalyst and K2S2O8 as the oxidant, this reaction enables the formation of a C-N bond and gives N-aroylsulfoximine products in moderate to excellent yields. The reaction mechanism is likely to involve the generation of a reactive aroyl radical intermediate.

Palladium-catalyzed ortho-acylation of N-Nitrosoanilines with α-oxocarboxylic acids: A convenient method to synthesize N-Nitroso ketones and indazoles

An efficient and mild protocol for regioselective synthesis of N-Nitroso aryl ketones by palladium-catalyzed direct acylation of arenes using N-Nitroso as directing groups is described. This reaction proceeded smoothly and could tolerate a variety of functional groups. Moreover, this chemistry offers a convenient access to a range of indazoles.

Pd-catalyzed decarboxylative ortho-acylation of O-methyl oximes with phenylglyoxylic acids

Aryl ketones were synthesized via Pd-catalyzed decarboxylative coupling between O-methyl oximes and phenylglyoxylic acids using (NH4) 2S2O8 as the oxidant. The Royal Society of Chemistry 2013.

Diphenylparabanic acid as a synthon for the synthesis of α-diketones and α-ketocarboxylic acids

Diphenylparabanic acid was found to react with >2 equiv of organolithiums at -78 °C to effectively give the corresponding symmetrical α-diketones. However, upon treatment with 1 equiv of organolithium, the parabanic acid gave mainly 5-substituted 5-hydroxyimidazolidine-2,4-diones. On the other hand, Grignard reagents were less reactive toward the parabanic acid at low temperature, and selectively gave the corresponding 5- hydroxyimidazolidine-2,4-diones even if more than 1 equiv of the reagents was used. A tandem process in which the parabanic acid was first reacted with a Grignard reagent and then reacted in one-pot with an organolithium effectively gave the unsymmetrical α-diketone. 5-Substituted 5-hydroxyimidazolidine-2, 4-diones were useful as versatile precursors for preparing α- ketocarboxylic acids as well as unsymmetrical α-diketones.

AMINO SUBSTITUTED PYRIMIDINES AND TRIAZINES

Pyrimidines and triazines of formula (I) wherein R is C 1-6alkyl, amino, mono-or diC 1-6alkylamino; R 1 is hydrogen, C 1-6alkyl, C 3-6alkenyl, hydroxyC 1-6alkyl or C 1-6alkyloxy-C 1-6alkyl; R 2 is C 1-6alkyl, mono-or diC 3-6cycloalkylmethyl, phenylmethyl, substituted phenylmethyl, C 1-6alkyloxy-C 1-6alkyl, hydroxyC 1-6alkyl, C 1-6alkyloxycarbonylC 1-6alkyl, C 3-6alkenyl; or R 1 and R 2 taken together with the nitrogen to which they are attached may form a pyrrolidinyl, morpholinyl or piperidinyl group; X is N or CR 3; R 3 is hydrogen or C 1-6alkyl; R 4 is phenyl or substituted phenyl; A is or--CR 7R 8--wherein R 5 and R 6 each independently are hydrogen or C 1-4alkyl; R 7 is hydrogen or OH, R 8 is hydrogen or C 1-6alkyl; having CRF receptor antagonistic properties; pharmaceutical compositions containing these compounds as active ingredients; methods of treating disorders related to hypersecretion of CRF such as depression, anxiety, substance abuse, by administering an effective amount of a compound of formula (I).