861967-36-4Relevant academic research and scientific papers
A novel class of AMPA receptor allosteric modulators. Part 1: Design, synthesis, and SAR of 3-aryl-4-cyano-5-substituted-heteroaryl-2-carboxylic acid derivatives
Fernandez, Maria-Carmen,Castano, Ana,Dominguez, Esteban,Escribano, Ana,Jiang, Delu,Jimenez, Alma,Hong, Eric,Hornback, William J.,Nisenbaum, Eric S.,Rankl, Nancy,Tromiczak, Eric,Vaught, Grant,Zarrinmayeh, Hamideh,Zimmerman, Dennis M.
, p. 5057 - 5061 (2007/10/03)
The synthesis and initial SAR studies of novel, highly potent positive allosteric modulators of AMPA receptors based on 3-(4-tert-butylphenyl)-4-cyano-5-methylsulfanyl-thiophene-2-carboxylic acid (6a) are described. SAR studies at the thioether moiety ind
THIOPHENE AND FURAN COMPOUNDS
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Page/Page column 135, (2010/02/13)
The present invention relates to thiophene and furan compounds and their pharmaceutically acceptable salts, and further relates to their use in treating schizophrenia, cognitive deficits associated with schizophrenia, Alzheimer's disease, dementia of the Alzheimer's type, mild cognitive impairment, or depression.
