861966-46-3Relevant articles and documents
A novel class of AMPA receptor allosteric modulators. Part 1: Design, synthesis, and SAR of 3-aryl-4-cyano-5-substituted-heteroaryl-2-carboxylic acid derivatives
Fernandez, Maria-Carmen,Castano, Ana,Dominguez, Esteban,Escribano, Ana,Jiang, Delu,Jimenez, Alma,Hong, Eric,Hornback, William J.,Nisenbaum, Eric S.,Rankl, Nancy,Tromiczak, Eric,Vaught, Grant,Zarrinmayeh, Hamideh,Zimmerman, Dennis M.
, p. 5057 - 5061 (2007/10/03)
The synthesis and initial SAR studies of novel, highly potent positive allosteric modulators of AMPA receptors based on 3-(4-tert-butylphenyl)-4-cyano-5-methylsulfanyl-thiophene-2-carboxylic acid (6a) are described. SAR studies at the thioether moiety ind