86197-67-3Relevant articles and documents
Stereoselective Synthesis of β-Alkoxy- and β-Alkylthio-Acrylic Esters and Amides from β-Tosylacrylic Derivatives
Blaya, Salvador,Chinchilla, Rafael,Najera, Carmen
, p. 3617 - 3626 (1995)
A simple and stereoselective synthesis of β-alkoxy- and β-alkylthio-acrylic esters and amides (8) by nucleophilic vinylic substitution of the tosyl group by sodium alcoholates and thiolates of (E)-β-tosylacrylic derivatives (7), prepared by iodosulfonylation-dehydroiodination of acrylic compounds, is described.This methodology is applied to the synthesis of sinharine (8eh) a natural antifungal isolated from glycosmis cyanocarpa.