861975-55-5Relevant academic research and scientific papers
Discovery of novel A3 adenosine receptor ligands based on chromone scaffold
Gaspar, Alexandra,Reis, Joana,Kachler, Sonja,Paoletta, Silvia,Uriarte, Eugenio,Klotz, Karl-Norbert,Moro, Stefano,Borges, Fernanda
, p. 21 - 29 (2012)
A project focused on the discovery of new chemical entities (NCEs) as AR ligands that incorporate a benzo-γ-pyrone [(4H)-1-benzopyran-4-one] substructure has been developed. Accordingly, two series of novel chromone carboxamides placed at positions C2 (co
Chromone, a privileged scaffold for the development of monoamine oxidase inhibitors
Gaspar, Alexandra,Silva, Tiago,Yá?ez, Matilde,Vina, Dolores,Orallo, Franscisco,Ortuso, Francesco,Uriarte, Eugenio,Alcaro, Stefano,Borges, Fernanda
experimental part, p. 5165 - 5173 (2011/09/16)
Two series of novel chromone derivatives were synthesized and investigated for their ability to inhibit the activity of monoamine oxidase. The SAR data indicate that chromone derivatives with substituents in position 3 of γ-pyrone nucleus act preferably a
