861983-23-5Relevant academic research and scientific papers
An efficient synthesis of 5-aminolaevulinic acid (ALA)-containing peptides for use in photodynamic therapy
Rogers, Louis M.-A.,McGivern, Philip G.,Butler, Anthony R.,MacRobert, Alexander J.,Eggleston, Ian M.
, p. 6951 - 6958 (2005)
An efficient and cost-effective procedure has been devised for the preparation of urethane-protected 5-aminolaevulinic acid (5-ALA) dipeptide ester derivatives which avoids problems associated with the instability of 5-ALA under basic conditions. The procedure is also applicable to the direct synthesis of N-(α)-acetyl amino acid-ALA dipeptides in high enantiomeric purity as potential novel prodrugs for photodynamic therapy (PDT).
