862-21-5

Upstream product

• 63-91-2 L-phenylalanine 
• 350-09-4 N-trifluoroacetyl-L-phenylalanine 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 2577-90-4 methyl (2S)-2-amino-3-phenylpropanoate 
• 2261-95-2 2-trifluoromethyl-4-benzyl-Δ³-oxazolin-5-one 
• 113891-88-6 (S)-3-Phenyl-2-[(Z)-3-phenyl-2-(2,2,2-trifluoro-acetylamino)-acryloylamino]-propionic acid methyl ester 
• 111688-34-7 methyl ester of N-trifluoroacetyldehydrophenylalanylphenylalanine 
• 58219-58-2 2-trifluoromethyl-4-benzylidene-Δ²-oxazolin-5-one 

Downstream Products

• 68800-30-6 SS-phenylalanylphenylalanine hydrochloride 

Relevant academic research and scientific papers

The: Ortho -substituent on 2,4-bis(trifluoromethyl)phenylboronic acid catalyzed dehydrative condensation between carboxylic acids and amines

2,4-Bis(trifluoromethyl)phenylboronic acid is a highly effective catalyst for dehydrative amidation between carboxylic acids and amines. Mechanistic studies suggest that a 2:2 mixed anhydride is expected to be the only active species, and the ortho-substituent of boronic acid plays a key role in preventing the coordination of amines to the boron atom of the active species, thus accelerating the amidation. This catalyst works for α-dipeptide synthesis.