862080-91-9Relevant academic research and scientific papers
Privileged structure-based quinazolinone natural product-templated libraries: Identification of novel tubulin polymerization inhibitors
Liu, Ji-Feng,Wilson, Christopher J.,Ye, Ping,Sprague, Kevin,Sargent, Katie,Si, Ying,Beletsky, Galina,Yohannes, Daniel,Ng, Shi-Chung
, p. 686 - 690 (2007/10/03)
A focused quinazolinone natural product-templated library was designed and synthesized. Compounds from this privileged structure-based library were identified as antimitotic agents acting through destabilization of tubulin polymerization. The results suggested that 2 could be a privileged substructure.
Novel one-pot total syntheses of deoxyvasicinone, mackinazolinone, isaindigotone, and their derivatives promoted by microwave irradiation
Liu, Ji-Feng,Ye, Ping,Sprague, Kevin,Sargent, Katie,Yohannes, Daniel,Baldino, Carmen M.,Wilson, Christopher J.,Ng, Shi-Chung
, p. 3363 - 3366 (2007/10/03)
(Chemical Equation Presented) Total syntheses of deoxyvasicinone (1), mackinazolinone (2), and 8-hydroxydeoxyvasicinone (3) via novel microwave-assisted domino reactions, as well as a novel three-component one-pot total synthesis of isaindigotone (5) promoted by microwave irradiation, are reported. The efficient reaction process enabled us to rapidly access related natural product derivatives and to identify a new class of cytotoxic agents.
