862250-00-8Relevant academic research and scientific papers
Lipase-promoted dynamic kinetic resolution of racemic β-hydroxyalkyl sulfones
Kielbasinski, Piotr,Rachwalski, Michal,Mikolajczyk, Marian,Moelands, Marcel A. H.,Zwanenburg, Binne,Rutjes, Floris P. J. T.
, p. 2157 - 2160 (2005)
A series of racemic aryl β-hydroxyalkyl sulfones have been successfully transformed into the corresponding optically active O-acetyl derivatives in high yields (up to 80%) with enantiomeric excesses more than 99% using a dynamic kinetic resolution procedure, in which a lipase-promoted kinetic resolution is combined with a concomitant ruthenium-catalysed racemization of the substrates.
