862251-87-4Relevant academic research and scientific papers
Synthesis, biology, and modeling of a C-4 carbonyl C,D-seco-taxoid
Ferjancic, Zorana,Matovic, Radomir,Cekovic, Zivorad,Jiang, Yi,Snyder, James P.,Trajkovic, Vladimir,Saicic, Radomir N.
, p. 8503 - 8514 (2007/10/03)
A C,D-seco-paclitaxel derivative 26 was prepared from taxine and tested for biological activity. Chemical reactivity of the seco-compounds proved to be substantially modified, with respects to taxoids. The corresponding C,D-seco-taxoid does not show tubul
Synthesis, biological evaluation, and modeling of a C,D-seco-taxoid
Ferjancic, Zorana,Matovic, Radomir,Cekovic, Zivorad,Snyder, James P.,Radomir, N. Saicic
, p. 5049 - 5052 (2007/10/03)
A C,D-seco-paclitaxel derivative 12 was prepared and tested for biological activity. The key step in the synthesis was a free radical fragmentation of the bicyclic tertiary alcohol 7 under the conditions of the hypobromite reaction. The compound 12 showed
