911285-72-8Relevant articles and documents
Synthesis, biological evaluation, and modeling of a C,D-seco-taxoid
Ferjancic, Zorana,Matovic, Radomir,Cekovic, Zivorad,Snyder, James P.,Radomir, N. Saicic
, p. 5049 - 5052 (2005)
A C,D-seco-paclitaxel derivative 12 was prepared and tested for biological activity. The key step in the synthesis was a free radical fragmentation of the bicyclic tertiary alcohol 7 under the conditions of the hypobromite reaction. The compound 12 showed