862260-18-2Relevant academic research and scientific papers
Total synthesis and structural revision of biyouyanagin B
Nicolaou,Sanchini, Silvano,Wu, T. Robert,Sarlah, David
supporting information; experimental part, p. 7678 - 7682 (2010/09/05)
Figure Presented An intriguing chase of the newly reported biyouyanagin B leads to its total synthesis and structural revision from 1' to 1.
Construction of two vicinal quaternary carbons by asymmetric allylic alkylation: Total synthesis of hyperolactone C and (-)-biyouyanagin A
Du, Chao,Li, Liqi,Li, Ying,Xie, Zhixiang
supporting information; experimental part, p. 7853 - 7856 (2010/04/05)
Call on triple A: Palladium-catalyzed asymmetric allylic alkylation (Pd-AAA; see scheme) has enabled a concise and efficient synthesis of hyperolacto ne C and (-)-biyouyanagin A in only six (20% Overall yield) and seven (8% overall yield) steps, respectively. The enantiomers of these natural products were also prepared by exploiting the same methodology.
Total synthesis, revised structure, and biological evaluation of biyouyanagin A and analogues thereof
Nicolaou,Wu, T. Robert,Sarlah, David,Shaw, David M.,Rowcliffe, Eric,Burton, Dennis R.
supporting information; experimental part, p. 11114 - 11121 (2009/02/05)
Isolated from Hypericum species H. Chinese L. var. salicifolium, biyouyanagin A was assigned structure 1a or 1b on the basis of NMR spectroscopic analysis. This novel natural product exhibited significant anti-HIV properties and inhibition of lipopolysacc
Total synthesis and revised structure of biyouyanagin A
Nicolaou,Sarlah, David,Shaw, David M.
, p. 4708 - 4711 (2008/02/10)
(Chemical Equation Presented) It all adds up: A 12-step total synthesis of biyouyanagin A, an inhibitor of HIV replication, has revealed its structure, rendered it available for biological investigations, and allows the synthesis of analogues. The convergent synthesis involves two cascade sequences and a remarkably selective [2+2] cycloaddition reaction to forge the cyclobutane ring of the target molecule in the ultimate step.
